cytotoxic T lymphocyte

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cytotoxic T lymphocyte

CTL, cytotoxic T cell Immunology A subset of T cells with a CD8 receptor on the surface that recognizes and lyses malignant or virally-infected self cells bearing self, ie 'haplotype restricted', class I MHC molecules. See Helper cells, Perforin, Suppressor cells.


having a deleterious effect upon cells.

cytotoxic antibody
see cytotoxic antibody.
cytotoxic drugs
generally refers to those used in chemotherapy of neoplasms, e.g. cyclophosphamide, vincristine, etc.
cytotoxic T lymphocyte
see T lymphocyte.
References in periodicals archive ?
A low number of donor-specific cytotoxic T lymphocytes identifies patients in whom the immunosuppressive load can be safely reduced," the investigators concluded.
Vaccinia virus-specific CD8+ cytotoxic T lymphocytes in humans.
Many vaccine peptides have been developed for stimulation of patients' cytotoxic T lymphocytes to kill cancer cells.
Rotavirus-specific cytotoxic T lymphocytes appear at the intestinal mucosal surface after rotavirus infection.
Responses such as T cell proliferation (replication of white blood cells in laboratory tests), the production of interferon (produced by lymphocytes in response to a viral infection) and the production of cytotoxic T lymphocytes (killer T cells) were induced by the vaccine.
The vaccines will employ IDEC's PROVAX(TM) adjuvant to induce cytotoxic T lymphocyte responses to the tumor-associated antigens.
In in vivo and in vitro tests, Multikine has been shown to be a strong inducer of Natural Killer (NK) cells and cytotoxic T lymphocyte (CTL) activity, both of which are thought to be important in immune-boosting, anti-cancer responses.
This preclinical data highlights that BGB324, a first-in-class, highly selective small molecule inhibitor of the Axl receptor tyrosine kinase, used in combination with immune checkpoint inhibitors (anti-CTLA-4 and anti-PD-1) in mouse carcinoma models showed enhanced tumour clearance, survival and tumour infiltration of cytotoxic T lymphocytes compared with checkpoint inhibition alone.
IPSCs can also be established from mature cytotoxic T lymphocytes, thereby allowing cloning and expansion of functional antigen-specific cytotoxic cells that might be useful in cell-based therapy of cancer.
Price DA, O'callaghan CA, Whelan JA, Easterbrook PJ, Phillips RE Cytotoxic T lymphocytes and viral evolution in primary HIV-1 infection.
When the immune cells known as cytotoxic lymphocytes (including cytotoxic T lymphocytes and natural killer cells) are activated, "they produce a massive amount of perforin, yet the cells are fine," Voskoboinik said.
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