In a study by Gershenson et al, (7) of 112 patients with stage II-IV low-grade ovarian serous carcinoma, patients who underwent optimal cytoreduction
had a median disease-free survival of 26 months.
Traditionally, optimal cytoreduction
of ovarian cancer has been limited to abdominal disease.
Javitt, director of women's imaging at Mercy Medical Center, Baltimore, noted that CT may help determine whose cancer is resectable, in many institutions everyone is offered cytoreduction
Pai and colleagues report a small randomized controlled trial (RCT) examining whether men who receive 6 months of neoadjuvant androgen deprivation therapy for cytoreduction
recover faster whether they receive a monthly luteinizing hormone-releasing hormone agonist (LHRHa) or an injection every 3 months.
ORLANDO -- Chemotherapy that is given before surgery improves optimal cytoreduction
rates in patients with advanced epithelial ovarian cancer, a retrospective comparative study suggests.
and androgen signaling modulation by abiraterone acetate (AA) plus leuprolide acetate (LHRHa) vs LHRHa in localized high-risk prostate cancer (PCa): preliminary results of a randomized preoperative study (Abstract 4556)
Treatment includes therapeutic phlebotomy to keep the hematocrit below 45% and myelosuppressive cytoreduction
to reduce the hematopoietic cells.
It's been shown in numerous studies that women who receive their care from gynecologic oncologists have a significantly higher likelihood of receiving NCCN guidelines [recommended] therapy, optimal cytoreduction
, and better overall survival," Dr.
Neoadjuvant (treatment that is given before or with the primary treatment) hormonal therapy (HT) is used as a means for prostate gland cytoreduction
(decrease in number of cells, as in a tumor) in order to eliminate pubic arch (an arch formed by the pubic bones) interference and improve the ability to perform brachytherapy.
Known as cytoreduction
(cyto- means cell), this process is intended to vanquish both the observable tumor and the microscopic individual malignant cells.
EPP achieves the greatest degree of cytoreduction
, and allows higher radiation doses to be delivered to the ipsilateral hemithorax because the lung has been removed.
Patients with bulky disease may require neoadjuvant chemotherapy and/or primary interval cytoreduction