Direct and indirect antioxidant properties of inducers of cytoprotective
A promising new strategy is to identify nutrients and phytochemicals that can directly target intrinsic cytoprotective
mechanisms, including modulation of the expression of (1) genes involved in the detoxification of xenobiotics, (2) genes involved in the synthesis and regulation of intrinsic antioxidants and antioxidant enzymes, (3) genes involved in the regulation of inflammation, and (4) vitagenes.
Moreover, both substances keep the retina healthy due to their anti-oxidative, or cytoprotective
, and anti-inflammatory effects.
In this valuable contribution to current understanding of these multipotent cells which have both cytoprotective
and cytotoxic effects on retinal neurons, Reichenbach and Bringmann (physiologists, U.
A new approach would be the use of cytoprotective
agents that can also modulate the antioxidant defenses in the body and thus prevent mucosal damage and gastric ulceration.
So, the harmful effect of ethanol on astrocytes is mitigated by the silver nanoparticles, which act as a cytoprotective
agent," explained Javier Selva, a lecturer with the Department of Cell Biology, Immunology and Neuroscience and first author of the paper.
Beeson's presentation will be Discovery of Cytoprotective
Agents for Treatment of Retinal Degenerative Disease.
You are aware of data for the cytoprotective
effects of misoprostol for NSAID-induced GI complications but are not familiar with the data for proton-pump inhibitors (PPIs) for primary prevention of GI complications from NSAIDs.
They concluded that EER extract possesses antisecretory, cytoprotective
, and anti-ulcer activities against experimentally-induced gastric lesions.
TTI-1612 is a small, orally-available recombinant protein that has powerful cytoprotective
and anti-inflammatory effects.
Alternatively, women with lupus can take a progestin-only pill, but they should consider the fact that it offers less effective birth control compared with combination OCs, is probably not cytoprotective
against cyclophosphamide, and is associated with a higher risk of ectopic pregnancy.
They propose that this constitutes a stratified cellular response to oxidative stress, with the activation threshold for cellular injury requiring higher oxidative stress levels than those for cytoprotective