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6] When examined by electron microscopy, the cells contain multilamellar cytoplasmic inclusion bodies typical of those found in type II alveolar epithelial cells of the lung.
Cytoplasmic inclusion bodies were seen within esophageal epithelial cells in five birds and in epithelial cells of the bronchioli in four penguins.
Langerhans cells have cytoplasmic inclusion bodies known as Birbeck granules; a definitive diagnosis requires electron microscopy of Birbeck granules or CD 1 antigenic determinants by immunohistochemistry.

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