cytomegalovirus retinitis

Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to cytomegalovirus retinitis: Cytomegalovirus infection, Mycobacterium avium complex


inflammation of the retina.
retinitis circina´ta (circinate retinitis) circinate retinopathy.
cytomegalovirus retinitis opportunistic infection of the retina by cytomegalovirus, seen in immunocompromised patients; symptoms include retinal necrosis and hemorrhage, leading to blindness.
exudative retinitis exudative retinopathy.
retinitis pigmento´sa a group of diseases, frequently hereditary, marked by progressive loss of retinal response (as recorded by the electroretinograph), retinal atrophy, attenuation of retinal vessels, and clumping of the pigment, with contraction of the field of vision. It may be transmitted as a dominant, recessive, or X-linked trait and is sometimes associated with other genetic defects. It may become manifest at the age of two or three years, or it may follow a slow course over a period of years. There is no successful treatment or cure for the condition. Early diagnosis allows the patient to prepare for the eventual loss of vision.
retinitis proli´ferans a condition that may result from intraocular hemorrhage, with neovascularization and the formation of fibrous bands extending into the vitreous from the retina; retinal detachment may result.
suppurative retinitis retinitis due to pyemic infection.

cytomegalovirus retinitis

Ophthalmology CMV infection of the eye, a common opportunistic infection in AIDS, a complication of disseminated CMV infection Clinical Retinal inflammation, blindness Management Antivirals–eg, foscarnet, cidofovir, gancyclovir, systemically and as a ganciclovir implant Prognosis Without treatment, retinal necrosis, vision loss

cytomegalovirus retinitis

Abbreviation: CMV retinitis
The most common eye infection in patients with acquired immunodeficiency syndrome. This opportunistic infection is responsible for visual impairment and blindness if left untreated.
See also: retinitis

retinitis, cytomegalovirus (CMV retinitis) 

A rare, chronic, diffuse infection of the retina caused by the cytomegalovirus (CMV), a member of the herpesvirus group. It affects people with an impaired immune system as a result of either AIDS, organ transplantation or chemotherapy for some malignancies such as leukaemia. The signs are whitish retinal lesions, which look granular (not fluffy, cotton-wool spots). These lesions progress into retinal necrosis with absolute visual field loss in that area. The lesions are usually accompanied by haemorrhages. Eventually the lesions coalesce and involve the entire fundus, resulting in complete visual loss. In the initial phase of the disease most patients are usually asymptomatic while those with symptoms will complain of floaters, blurred vision, photopsia, scotomas, metamorphopsia, etc. In some cases, retinal detachment follows the disease. Treatment with dihydroxy propoxymethyl guanine and ganciclovir produces some regression of the disease. See acquired immuno-deficiency syndrome.
References in periodicals archive ?
Use of intravitreal ganciclovir (dihydroxy propoxymethyl guanine) for cytomegalovirus retinitis in a patient with AIDS.
Intravitreal ganciclovir in the treatment of AIDS-associated cytomegalovirus retinitis.
Cytomegalovirus retinitis in the era of highly active antiretroviral therapy.
Its product portfolio includes microkeratomes and blades for LASIK refractive surgery; an advanced excimer laser with a built-in LASIK workstation for refractive surgery; equipment and viscoelastics for cataract surgery; PMMA and foldable intraocular lenses (IOLs); and the Vitrasert Implant, the first drug delivery system to provide local, sustained therapy for the treatment of cytomegalovirus retinitis (CMV) in people with AIDS.
Food and Drug Administration for oral Cytovene(R) (ganciclovir sodium) for the maintenance treatment of cytomegalovirus retinitis in the first half of calendar 1994 and for mycophenolate mofetil for the prevention of acute kidney transplant rejection in the second half of calendar 1994.
The Medicines Control Agency approved 'Leucomax' in hospitals for chemotherapy-induced neutropenia in cancer patients, to accelerate recovery after autologous bone marrow transplantation, and to combat ganciclovir (DHPG)-induced neutropenia in AIDS patients with cytomegalovirus retinitis, which in most cases leads to blindness.
The CPMP recommended that 'Leucomax' be approved for chemotherapy- induced neutropenia in cancer patients, to accelerate recovery after autologous bone marrow transplantation, and to combat gancyclovir (DHPG)-induced neutropenia in AIDS patients with cytomegalovirus retinitis, which in most cases leads to blindness.
The web site features information about Gilead's antiviral product pipeline, including a currently available therapy for cytomegalovirus retinitis, as well as its products in clinical testing for the potential treatment of diseases caused by human immunodeficiency virus, hepatitis B virus, herpes simplex virus, human papillomavirus and influenza virus.
He has led the development of Gilead's antiviral product pipeline, spearheaded by VISTIDE, our product candidate for cytomegalovirus retinitis.
Food and Drug Administration and a Market Authorization Application submitted in December 1995 to the European Medicines Evaluation Agency for the systemic treatment of cytomegalovirus retinitis.
The Company's most advanced product under development is VISTIDE(TM) (cidofovir intravenous), which is the subject of a New Drug Application filed in October 1995 for the systemic treatment of cytomegalovirus retinitis.