cytomegalovirus

cytomegalovirus /cy·to·meg·a·lo·vi·rus/ (CMV) (-meg´ah-lo-vi″rus) any of a group of highly host-specific herpesviruses, infecting humans, monkeys, or rodents, producing unique large cells with intranuclear inclusions; the virus can cause a variety of clinical syndromes, collectively known as cytomegalic inclusion disease, although most infections are mild or subclinical.

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Cytomegalovirus /Cy·to·meg·a·lo·vi·rus/ (-meg´ah-lo-vi″rus) human cytomegaloviruses; a genus of ubiquitous viruses of the subfamily Betaherpesvirinae (family Herpesviridae), transmitted by multiple routes.

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cy·to·meg·a·lo·vi·rus (st-mg-l-vrs)

n.

Abbr. CMV Any of a group of herpes viruses that attack and enlarge epithelial cells. Such viruses also cause a disease of infants characterized by circulatory dysfunction and microcephaly. Also called visceral disease virus.

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Cytomegalovirus (CMV)

A common human virus causing mild or no symptoms in healthy people, but permanent damage or death to an infected fetus, a transplant patient, or a person with HIV.

Mentioned in: Antiviral Drugs, Bone Marrow Transplantation, Cytomegalovirus Antibody Screening Test, Maternal to Fetal Infections

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cytomegalovirus (CMV)

[sī′tōmeg′əlōvī′rəs]

Etymology: Gk, kytos + megas, large; L, virus, poison

a member of a group of large species-specific herpes-type viruses with a wide variety of disease effects. It causes serious illness in persons with human immunodeficiency virus, in newborns, and in people being treated with immunosuppressive drugs and therapy, especially after organ transplantation. The virus usually causes a retinal or GI infection. See also cytomegalic inclusion disease, TORCH syndrome.

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cytomegalovirus (sīˈ·tō·meˈ·g·lō·vīˑ·rs),

n species-specific, herpes-type virus capable of causing life-threatening illness in HIV patients, transplant recipients, and newborns; typically causes gastrointestinal or retinal infections.

Cytomegalovirus.

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Cytomegalovirus (CMV),

n a visceral disease virus, a member of the group of herpesviruses having special affinity for the salivary glands. Considered one of the indicator infections of AIDS.

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cytomegalovirus

member of the Betaherpesvirinae subfamily, they infect humans, monkeys, pigs and rodents in which they appear to establish life-long infections. The viruses are highly host specific, slow growing, remain highly cell-associated and produce large intranuclear inclusion bodies in enlarged cells. Diseases produced by cytomegaloviruses are subtle.

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mouse cytomegalovirus

causes subclinical infection of submaxillary salivary glands and other tissues in wild mice.

porcine cytomegalovirus

causes inclusion body rhinitis and a generalized infection in young pigs.

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TORCH panel

TORCH antibody panel Pediatrics A serologic screen for diagnosing prenatal infection; the finding of ↑ IgM in the neonate implies in utero infection by one of the TORCH agents–toxoplasma, rubella, CMV, herpes simplex, which is then characterized by measuring specific IgM levels.

TORCH agents  

Toxoplasmosis may cause periventricular microglial nodules, thrombosis and necrosis; obstruction of cerebral foramina causes hydrocephalus; with prolonged survival, there is intracranial calcification, hepatocellular, adrenal, pulmonary, cardiac necrosis and extramedullary hematopoiesis

Rubella may cause LBW, hepatosplenomegaly, petechiae and purpura, congenital heart disease, cataracts, microophthalmia and microcephaly; CNS symptoms include lethargy, irritability, dystonia, bulging fontanelles and seizures. Cf Congenital rubella syndrome.

Cytomegalovirus may cause hepatosplenomegaly, hyperbilirubinemia, neonatal thrombocytopenia, microcephaly and a mortality of 20-30%; later manifestations include mental retardation, deafness, psychomotor delays, dysodontogenesis, chorioretinitis, learning disabilities; ± 33 000 congenital cases/year–US, of which 10% are symptomatic

Herpes simplex may cause prematurity, and becomes symptomatic after the first week of life; CNS symptoms include irritability, seizures, chorioretinitis, hydrocephalus, flaccid or spastic paralysis, opisthotonos, decerebrate rigidity and coma; in neonatal HSV infection, no deaths occur in those with localized disease, 15% die if encephalitis is present and 57% die if HSV is disseminated, potentially evoking DIC NEJM 1991; 324:450

Syphilis–an optional 'TORCH' Congenital syphilis has ↑ to epidemic rates in the urban US since the mid-1980s; the clinical findings are nonspecific and include fever, lethargy, failure to thrive, and irritability  

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Patient discussion about cytomegalovirus.

Q. Do you want to end because of a vaccination in a wheel chair? It is already about 12 years ago. I met a mother with her kids. One came always in a wheel chair to the services. His terrible story is still in my mind. It could be shown, that because of a vaccination he got the cytomegalovirus infection (CMV) and then spastic paralysis.

A. Corrigendum: If you know somebody speaking German and English who could...

Q. What is it CMV during pregnancy ? can i infect with that?

A. CMV or cytomegalovirus (http://en.wikipedia.org/wiki/Cytomegalovirus) is a virus that can cause disease (i.e. infectious mononucleosis, http://en.wikipedia.org/wiki/Infectious_mononucleosis) in everyone, not only pregnant women. The problem is that when a pregnant woman is infected in CMV for the first time of her life during pregnancy, CMV can cause malformations and problems with the baby, including hearing impairment and others (see also TORCHES: http://en.wikipedia.org/wiki/TORCH_infections).

Q. What is it CMV during pregnancy? can i infect with that?

A. CMV is a virus. What you refer to is infection with CMV, either the initial infection, or re-activation of latent (dormant) virus that resides in the mother's body during pregnancy.

The dangers are that CMV will infect the fetus, which may cause malformations, particularly growth restriction and hearing impairment.

You may read more here:
www.nlm.nih.gov/medlineplus/cytomegalovirusinfections.html