Munc 13-4 is essential for cytolytic
granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis(FLH3).
C8[gamma] is also not essential for incorporation of C8 into the MAC nor is it required for MAC cytolytic
Human serum induces maturation of human monocytes in vitro, changes in cytolytic
activity, intracellular lysosomal enzymes and nonspecfic esterase activity.
P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7).
C8g is a 22-kDa subunit of C8, which is one of five proteins that form the cytolytic
"membrane attack complex" (MAC) of complement.
Purification and characterization of a cytolytic
protein from purple ink of the sea hare, Dolabella auriculata.
vulnificus produce multiple toxins including collagenase and cytolytic
and proteolytic substances containing mucinase, protease, lipase, deoxyribonuclease, chondroitin sulfate, and hyaluronidase, which are associated with extensive tissue damage and may play a major role in the development of sepsis.
The latter function has been described to involve a synergistic interaction between IL-1 and IL-6 on the induction of cytolytic
T-lymphocyte responses (Akira et al.
The effect of lowering cellular levels of cyclic 3', 5' adenosine monophosphate (cAMP on the cytolytic
function and phospholipase C (PLC)[gamma] activity of natural killer (NK) cells has not been studied.
or Type II reactions can be mediated by both IgG and IgM antibodies.
The other depends heavily on T cells -- not helper, but cytolytic
CD8 T cells -- that can destroy tumors or cells infected with viruses or bacteria.
The final section, on peptide toxins, contains a review of the work on conotoxins, the biologically active peptides in cone snail venom; sea anemone polypeptide toxins that affect sodium channels; and chapters on sea snake venom (neurotoxins), the cytolytic
peptides found in sea anemones, some natural jellyfish toxins, plus an article on pardaxin, the neurotoxic polypeptide from the Red Sea Moses sole, Pardachirus marmoratus, which targets gills and pharynx of aquatic animals and is eyed as a shark repellant.