Our study is the first to date, to our knowledge, to look at an institution with a restricted and regulated atypical diagnostic category for all nongynecologic cytologic specimens
Because many cytologic specimens
are submitted in the fresh state, the date of collection has special significance for cytopathology.
Additionally, TTF-1 was observed to have a high nuclear affinity, allowing for greater confidence when confirming positivity in cytologic specimens
compared with napsin A, because the latter also stained alveolar macrophages.
For clinical validation of the assay, we evaluated a total of 50 cytologic specimens
for the presence of HPV DNA.
For decades, it has been recognized in exfoliative cytologic specimens
that viral infections of the upper respiratory tract and benign reserve cell hyperplasia may cause confusion with squamous cell and small cell carcinomas, respectively.
The Ikeda group (12) found that EMA staining had 100% sensitivity and 74% specificity in alcohol-fixed cytologic specimens
in a study that included 11 epithelioid mesotheliomas (10 thoracic) and 50 benign effusions.
After implementation, 92% of cytologic specimens
came from gastroenterology compared with 59% before implementation (P < .
Polymerase chain reaction-based detection of B-cell monoclonality in cytologic specimens
In their review of cytologic specimens
with histology correlation, they correctly subclassified 36% of the MCs compared to 86% of the infiltrating ductal carcinomas, 75% of the infiltrating lobular carcinomas, and 93% of the medullary carcinomas.
9%) with LSIL vaginal Pap test results who had vaginal biopsies, and all 7 patients with VAIN 2/3 diagnoses had hrHPV DNA detected in their vaginal cytologic specimens
Stability of archived liquid- based cervical cytologic specimens
We actually reported no major changes in diagnosis for the cytologic specimens
(except minor descriptive changes to the report).