cytokine storm


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A potentially fatal hyperrelease of inflammatory mediators in response to stimulation of T cells and macrophages by pathogens and immune insults
Triggers Graft versus host disease, adult respiratory distress syndrome, sepsis, avian influenza, and systemic inflammatory response syndrome

cytokine storm

The massive release of interleukins, tumor necrosis factor alpha, and other circulating mediators of inflammation during critical illness. These agents may trigger bleeding, clotting, internal organ injury, or shock.
See also: storm
References in periodicals archive ?
To learn more about Ricerca's Early Safety Screening Cytotoxicity or ImmunoSIGNAL[TM] Cytokine Storm Cellular Assay, contact 1-888-RICERCA (742-3722).
Our first product candidate GP1001 uniquely treats influenza infection by tempering the cytokine storm," said William Guilford PhD, President, Gemmus.
We do not know how long ago this virus emerged, how deadly it is, whether it has pandemic potential, how the severity of infection relates to patient age, and why some infected patients die-whether a cytokine storm is responsible for these deaths," he says.
He further says what scientists know is that some H1N1 viruses have pandemic potential, and that historical evidence supports the possibility that young healthy adults may be especially susceptible to more severe infection and poor outcomes due to the ability of a strong immune system to initiate a cytokine storm.
Antiviral drugs being stockpiled as part of a global strategy to treat Avian Flu have no therapeutic value once the cytokine storm has been triggered.
If the cytokine storm has already been triggered, antiviral drugs aren't going to turn it off.
The March 2, 2006 issue of The Lancet reported that researchers at the well-regarded Karolinska Institute in Stockholm are proposing the use of chemotherapy to kill off excess immune cells as a means to curb the cytokine storm leading to viral sepsis in H5N1 patients.
Antiviral drugs are not able to shut off a cytokine storm once it has been triggered.
Before I conclude, I should comment on the potential use of CytoSorb as a rescue therapy for "cytokine release syndrome", or CRS, that can lead to cytokine storm in activated T-cell immunotherapy cancer treatments.
We call them cytokine storms - when events which cause changes in chemicals in your body have a significant effect on disease progress.
This linkage leads to the nonspecific activation of large numbers of regulatory T lymphocytes, producing cytokine storms that can have a variety of serious clinical consequences.
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