cytokine inhibitors

cytokine inhibitors; anti-TNF alpha agents biological disease-modifying antirheumatic drugs (DMARDs) that inhibit tumour necrosis factor-alpha formation; used to treat autoimmune- mediated inflammatory conditions (ankylosing spondylitis and rheumatoid arthritis); e.g. infliximab; adalimumab, enteracept
References in periodicals archive ?
Several attempts to control chronic inflammation generally utilizes approaches like systemic steroids, anti-inflammatory pharmacologic agents, cytokine inhibitors that lead to profound immune-suppression leading to increased risk of infections as well as secondary auto-immune diseases.
36) evaluated the involvement of proinflammatory cytokines (IL-6, IL-8), cytokine inhibitors (IL-6sR, TNFRII), and anti-inflammatory cytokines (IL-10, IL-13) in the progress child sepsis.
Proinflammatory cytokines (IL-6, IL-8), cytokine inhibitors (IL-6sR, sTNFRII) and anti-inflammatory cytokines (IL-10, IL-13) in the pathogenesis of sepsis in newborns and infants.
Yet several trials have shown that patients who do not respond to traditional antidepressants frequently begin to improve when they take anti-inflammatory medications, from everyday ibuprofen to cytokine inhibitors, on top of their other prescriptions.
Fourteen trials informed the meta-analysis, 10 that evaluated NSAID drugs (for example, celecoxib, naproxen, ibuprofen), and 4 that investigated cytokine inhibitors (for example, etanercept, infliximab).
Fourteen trials informed the meta-analysis: 10 that evaluated NSAID drugs (for example, celecoxib, naproxen, ibuprofen), and 4 that investigated cytokine inhibitors (for example, etanercept, infliximab).
Cytokine inhibitors are substances that inhibit the biological activities of specific cytokines, which are small proteins releasee by cells that have a specific effect on the interactions between cells, or on the behavior of cells.
Massague's website at the Sloan-Kettering Institute further clarifies the current research: "TGF-[beta] is the most prominent cytokine inhibitor of cell proliferation.
Through this acquisition Cephalon will gain rights to the BDC intellectual property estate covering the use of cytokine inhibitors, including TNF inhibitors, for sciatic pain in patients with intervertebral disk herniation, as well as other spinal disorders.
Nine chapters are new to this edition, on cytokine inhibitors, potential biologic therapies, pain mechanisms and management, vasculitis classification, Wegener's and anti-neutrophil cytoplasmic antibody-associated vasculitis, polyarteritis nodosa and microscopic polyarterities, hypersensitivity vasculitis, Behcet's syndrome, and other vasculitis syndromes.
The combined use of such cytokine inhibitors, including inhibitors to TNF-alpha, interferon-alpha (IFN-alpha) and interferon-gamma (IFN-gamma) to treat AIDS is protected by the Company's intellectual property.