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See also: interferon, interleukin, lymphokine.
Most cytokines are small (less than 30 kD) soluble proteins or glycoproteins. Produced by macrophages, B and T lymphocytes, mast cells, endothelial cells, fibroblasts, and stromal cells of the spleen, thymus, and bone marrow, they act nonenzymatically through specific receptors to regulate immune responses, in particular modulating the balance between humoral and cell-mediated responses. They are involved in mediating immune and allergic responses by regulating the maturation, growth, and responsiveness of particular cell populations, sometimes including the cells that produce them (autocrine activity). A given cytokine may be produced by more than one type of cell. Some cytokines enhance or inhibit the action of other cytokines. Their complex synergistic and antagonistic interactions fully justify the expression cytokine network. The first cytokines to be identified were named according to their functions (for example, T-cell growth factor), but this nomenclature became awkward because several cytokines can have the same function, and the function of a cytokine can vary with the circumstances of its elaboration. Later, as the chemical structure of each cytokine was determined, it was designated an interleukin and assigned a number (for example, interleukin-2 [IL-2], formerly T-cell growth factor). Cytokines have been implicated in the generation and recall of long-term memory and the focusing of attention. Some degenerative effects of aging may be due to a progressive loss of regulatory capacity by cytokines. Because cytokines derived from the immune system (immunokines) are cytotoxic, they have been used against certain types of cancer. Their clinical usefulness is limited by their short half-life and their wide-ranging and unpredictable side-effects.
cytokine/cy·to·kine/ (si´to-kīn″) a generic term for nonantibody proteins released by one cell population on contact with specific antigen, which act as intercellular mediators, as in the generation of an immune response.
cytokineBiological response modifier Any of a number of small 5–20 kD polypeptide signaling proteins of the immune system, which are produced by immune cells and have specific effects on cell-cell interaction, communication and behavior of other cells. See Biological response modifiers, Colony stimulating factor(s. ), Fibroblast growth factor, Interferons, Interleukins, Platelet-derived growth factor, Transforming growth factor β, Tumor necrosis factor.
See also: interferon, interleukin, lymphokine
cytokineintercellular PROTEIN or GLYCOPROTEIN signalling molecule, secreted by many cell types and involved in cellular regulation and proliferation. Cytokines exert their effects by binding to specific RECEPTORS on the membrane of target cells. They include GROWTH FACTORS, INTERLEUKINS and LYMPHOKINES.
antitumour necrosis factor (anti-TNF); anti-TNF-a agents; cytokine antibody to TNF-a used to control inflammation and vasculitis, and effect tissue repair in rheumatological diseases (e.g. rheumatoid arthritis, ankylosing spondylitis and psoriasis); indicated for rheumatoid arthritis patients who have not responded to at least two standard disease-modifying antirheumatism drugs, including methotrexate
See: interferon, interleukin