KRT18

(redirected from cytokeratin-18)

KRT18

A gene on chromosome 17q21.2 that encodes a type-I keratin, an intermediate filament protein. Together with its filament partner keratin 8, they are the most commonly expressed of all intermediate filaments, and found in tissues lined by single layer epithelia.
 
Molecular pathology
KRT18 mutations are associated with cryptogenic cirrhosis.
References in periodicals archive ?
Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: A multicenter validation study.
Plasma levels of caspase-generated cytokeratin-18 fragments, a marker of hepatocyte apoptosis, have also been used to identify NASH (non alcoholic steatohepatitis).
The ELISA measures the accumulation of a caspase-cleaved fragment of cytokeratin-18 (CK18-Asp396) in cells and tissue culture medium over time (Kramer et al.
Plasma caspase activation was detected using an enzyme-linked immunosorbent assay for cytokeratin-18 fragments, which are a byproduct of caspase activation.
In a prospective study of 59 randomly selected patients with chronic hepatitis C virus (HCV) infection, a high degree of inflammatory liver injury on liver biopsy was associated with greater levels of the products that result from the cleavage of cytokeratin-18 (CK-18, a major intermediate filament protein in liver cells) by caspases during apoptosis (Hepatology 2004;40:1078-87).