KRT14

(redirected from cytokeratin-14)

KRT14

A gene on chromosome 17q12-q21 that encodes a type-I intermediate filament keratin, which typically forms a heterotetramer with KRT5 (type-II) keratins that together form the cytoskeleton of epithelial cells.

Molecular pathology
KRT14 mutations are associated with epidermolysis bullosa simplex.
References in periodicals archive ?
Localization of cytokeratin-14 in the basal layer and presence of cytokeratin-10 in the supra-basal layers verified an anatomically correct differentiation of the epidermis.
Physiological differentiation was confirmed by immunohistological staining, showing a physiological location of cytokeratin-14 in the basal layer and cytokeratin-10 in the suprabasal layers (Fuchs, 2009).
Positive binding of primary antibodies against collagen type IV (Col IV), cytokeratin-14 (CK-14), cytokeratin-10 (CK-10), and filaggrin (filagg.