KRT8

(redirected from cytokeratin 8)

KRT8

A gene on chromosome 12q13.13 that encodes a type-II cytokeratin that heteropolymerises to form intermediate filaments in epithelial cell cytoplasm. The KRT 8 typically dimerises with KRT 18 to form an intermediate filament in simple single-layered epithelial cells. KRT8  plays a role in maintaining cellular structural integrity, in signal
transduction and cell differentiation.

Molecular pathology
KRT8 mutations cause cryptogenic cirrhosis.
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References in periodicals archive ?
Triple-label immunofluorescence for Bax, CYP1A1, and cytokeratin 8/18 localizes the expression of Bax and CYP1A1 in alveolar type II cells (alveolar type II cells contain abundant cytokeratin 8 and cytokeratin 18).
The system uses polyclonal antibodies, and data indicate that they recognize the rod domain of the cytokeratin 8, 18, and 19 fragments; however, the exact structure of the binding epitope is unknown.
For HCC biomarkers, alpha-fetoprotein (AFP, 19-fold), plasminogen activator inhibitor-1 (PAI-1, 9-fold), cytokeratin 8 (6-fold), cytokeratin 18 (3-fold) and cytokeratin 19 (11-fold), were dramatically increased in arsenic-induced HCC.
The HCC biomarkers cytokeratin 8 and plasminogen activator inhibitor 1 (PAI-1) were all significantly increased in arsenic-induced HCC, and also higher in arsenic-exposed tumor-surrounding tissues.
10] These cells have been shown to react with cytokeratin 8 (CK8) and cytokeratin 18 (CK18) antibodies, and the cytokeratin immunoreactivity can be variable, depending on the antibody used.