KRT19

(redirected from cytokeratin 19)

KRT19

A gene on chromosome 17q21.2 that encodes the smallest of all type-I keratin proteins, which is expressed in the periderm, the transiently superficial layer that surrounds the developing epidermis.
References in periodicals archive ?
83-86) The main histologic mimic is squamous cell carcinoma, and a panel of cytokeratin 19 and cytokeratin 7 is considered helpful.
Prognostic value of the molecular detection of circulating tumor cells using a multimarker reverse transcription-PCR assay for cytokeratin 19, mammaglobin A, and HER2 in early breast cancer.
The CYFRA 21-1 assay kit is indicated for the quantitative determination of soluble cytokeratin 19 fragments in human serum.
Identification of a novel cytokeratin 19 pseudogene that may interfere with reverse transcriptase-polymerase chain reaction assays used to detect micrometastatic tumor cells.
More recently, differential mRNA expression of cytokeratin 19 (CK19) and mammaglobin in breast epithelial cells versus lymphoid cells has been used to develop a real-time RT-PCR assay (GeneSearch[TM] BLN Assay, Veridex, LLC, Warren, NJ) to detect sentinel lymph node metastasis intraoperatively by assessing the homogenate of the nodal tissue [27-31].
For HCC biomarkers, alpha-fetoprotein (AFP, 19-fold), plasminogen activator inhibitor-1 (PAI-1, 9-fold), cytokeratin 8 (6-fold), cytokeratin 18 (3-fold) and cytokeratin 19 (11-fold), were dramatically increased in arsenic-induced HCC.
Cyfra 21-1 is a 40 kDa fragment derived from cytokeratin 19.
The Cyfra 21-1 EIA kit is indicated for the quantitative determination of soluble cytokeratin 19 fragments in human serum.
Immunohistochemical stains using a pancytokeratin cocktail (AE1/3) and an antibody directed against cytokeratin 19 were strongly positive in the glandular and squamous areas and focally positive in the more differentiated fetal and embryonal hepatoblastoma areas.
positive results for thyroglobulin and thyroid transcription factor-1; a distinctive cell-membrane staining pattern for MIB-1; negative results for calcitonin and HBME-1; and either positive or negative results for cytokeratin 19, which is strongly and diffusely positive in papillary carcinoma (2, 3).
Cytokeratin 19 expression was cytoplasmic, CITED1 expression was nuclear and cytoplasmic, and HBME1 expression was membranous, apical, and cytoplasmic (Figure 2, A through D).
Some markers, including cytokeratin 19 fragment (CYFRA 21-1), carcinoembryonic antigen (CEA), squamous cell carcinoma antigen, and neuron-specific enolase, are now used in clinical practice for lung cancer diagnosis.