KRT18

(redirected from cytokeratin 18)

KRT18

A gene on chromosome 17q21.2 that encodes a type-I keratin, an intermediate filament protein. Together with its filament partner keratin 8, they are the most commonly expressed of all intermediate filaments, and found in tissues lined by single layer epithelia.
 
Molecular pathology
KRT18 mutations are associated with cryptogenic cirrhosis.
References in periodicals archive ?
2), actin, vimentin and cytokeratin 14 and negative for cytokeratin 18 and 19.
In vitro expression of cytokeratin 18, 19 and tube formation of adipose-derived stem cells induced by the breast epithelial cell line HBL-100," Journal of Cellular and Molecular Medicine, vol.
M30 antibody detects degraded fragments of cytokeratin 18 (dCK18) in the cytoplasm of a cell undergoing apoptosis and is considered the cytoplasmic end product of apoptosis.
A and B, Photomicrographs showing focal faint cytoplasmic positivity for M30/fragmented cytokeratin 18 immunostain in both crypts and villi of duodenal biopsy specimens from controls.
This assay provides an integrative measure of apoptosis based on the accumulation of a caspase-cleavage product of cytokeratin 18 (ccCK18) in cells and culture medium.
Levels of cytokeratin 18, a potential marker of disease activity in Non-alcoholic Fatty Liver Disease (NAFLD), decreased by an average of 45%.
The TPS assay is a monoclonal test specific to the M3-binding region on cytokeratin 18.
Immunohistochemical detection of cytokeratin 18 and its neo-epitope in human salivary glands and pleomorphic adenomas," Anticancer Research, vol.
16) Cytokeratin 18 is reactive in the physaliphorous cells, a supposed, but questionable, distinction from fetal notochordal tissue (see below).
For HCC biomarkers, alpha-fetoprotein (AFP, 19-fold), plasminogen activator inhibitor-1 (PAI-1, 9-fold), cytokeratin 8 (6-fold), cytokeratin 18 (3-fold) and cytokeratin 19 (11-fold), were dramatically increased in arsenic-induced HCC.
20] It is a monoclonal antibody called M30, which recognizes a neoepitope of cytokeratin 18 (CK18) in paraffin-embedded tissue.
10] These cells have been shown to react with cytokeratin 8 (CK8) and cytokeratin 18 (CK18) antibodies, and the cytokeratin immunoreactivity can be variable, depending on the antibody used.