On the other hand, T24 cells needed more than 30 minutes of exposure to sterile water to have a cytocidal
p21 and PUMA mRNAs are markers of leukocytes' cytostatic and cytocidal
Therefore, the discovery of active natural products with cytocidal
STUDY SUMMARY: The goals of the Phase I/II study were to evaluate the overall safety and efficacy of intravenous infusions of Rexin-G, a tumor-targeted retrovector bearing a cytocidal
anti-cyclin G1 construct, in gemcitabine-resistant pancreas cancer.
The first article entitled "Rexin-G, A Targeted Genetic Medicine for Metastatic Cancer" (Expert Opinion on Biological Therapy, May, 2010) documents the development of Rexin-G: a tumor-targeted retrovector bearing a cytocidal
cyclin G1 construct; the first targeted gene therapy vector to gain FDA Fast Track designation and Orphan Drug priorities for multiple cancer indications in the USA.
The antimicrobial activity observed was always cytocidal
and the MFC values were the same of the MIC ones.
Reximmune-C incorporates a powerful cytokine gene, in place of the cytocidal
gene used in Rexin-G, to deliver an immune- stimulating pulse to activate a patient's own immune cells in the area of residual tumors to prevent recurrence.
Influences of different polychlorinated biphenyls on cytocidal
, mitoinhibitory, and nodule-selecting activities of N-2-fluorenylacetamide in rat liver.
Rexin-G and Reximmune-C are pathotropic (disease-seeking) nanoparticles bearing a cytocidal
cyclin G1 gene and a granulocyte-macrophage colony stimulating factor (GM-CSF) gene, respectively.
And we quote, "A third example is represented by the first and so far only targeted vector that has been tested in the clinic: the retroviral vector Rexin-G, which expresses a cytocidal
dominant-negative form of cyclin G1.
Ono Y, Kozai Y, Ootsu K (1982) Antitumor and cytocidal
activities of a newly isolated benzenoid ansamycin, macbecin I Gann 73: 938-944
The unirradiated mice spleen did not have any shortage of stem cells due to the absence of a cytocidal
agent like radiation.