Prominent among these are Cyp genes including Cyp2a4 and Por (NADPH cytochrome
2C9 shows very good agreement with the Lewis P450 Model
Reductive metabolism of p,p'-DDT and o,p'-DDT by rat Diver cytochrome
Closely related genes encode developmental and tissue isoforms of porcine cytochrome
Keywords: Mistletoe extract; Herb-drug interaction; Hepatocyte viability; Cytochrome
P450 inhibition; Cytochrome
Reduced glutathione (GSH), 1-chloro-2,4-dinitrobenzene (CDNB), reduced nicotinamide adenine dinucleotide phosphate (NADPH), amidopyrine, cytochrome
C, thiobarbituric acid and all other chemicals were purchased from Sigma Chemical Company (Saint Louis, USA).
This agreement is another example of Astex's commitment to making its human cytochrome
P450 technology available to other companies who could benefit or are already benefiting from its application in the discovery and development of novel drugs with reduced metabolic liabilities.
This article examines alcohol metabolism in the liver by the enzyme cytochrome
P450 2E1 (CYP2E1) and the role of this enzyme in creating a harmful condition known as oxidative stress.
CYP3A enzymes are the predominant cytochrome
P450 proteins in the human liver and play an important role in the metabolism of numerous exogenous and endogenous substrates.
The other pathway is mediated by cytochrome
P450 2E1, an enzyme bound to the network of membranes within the cell known as the endoplasmic reticulum.
Astex has been actively involved in human cytochrome
P450 research since the company's formation and Astex scientists were the first group to successfully solve the crystal structures of human cytochromes
P450, 3A4 and 2C9(3).
Significant increases in the levels of acid-soluble sulfhydryl (-SH) and cytochrome