cytochrome c oxidase


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cy·to·chrome c ox·i·dase

(sī'tō-krōm oks'i-dās),
A cupriferous cytochrome of the a type that catalyzes the oxidation of four molecules of ferrocytochrome c by molecular oxygen to produce four molecules of ferricytochrome c and 2H2O. A part of Complex IV of the respiratory chain. A deficiency of one or more of the polypeptides of this complex results in neuronal loss in the brain leading to psychomotor retardation and neurodegenerative disease.
References in periodicals archive ?
Cytochrome C oxidase activity: Cytochrome C oxidase reaction is shown bluish brown to brownish black in the micrograph of MII oocytes (Figure 1).
This result may be due to encoding of some cytochrome C oxidase subunits by mitochondrial genome whereas total subunits of succinate dehydrogenase are encoded by nuclear genome.
On the other hand T2 target protein was found to interact with cbb3-type cytochrome c oxidase subunit II (ccoO) involved in the transfer of electron from cytochrome c to catalytic subunit I and ubiquinol-cytochrome C reductase cytochrome B subunit (petB) involved in ATP generation (Table 6).
The 3D structure of best active site of T2 (ccoN:cbb3-type cytochrome c oxidase subunit I) by CASTp and (B) Active site information of T2that is most highly positioned in area 2397.
Surprisingly, MCI PBMCs showed higher activities of two enzymes regulating the energy machine, cytochrome C oxidase and citrate synthase, involved in the respiratory chain processes and Krebs cycle, respectively.
Ferrer, "Dystrophic neurites of senile plaques in Alzheimer's disease are deficient in cytochrome c oxidase," Acta Neuropathologica, vol.
Our results revealed that the activity of cytochrome c oxidase has been increased with increasing amount of copper, in spite of the reduction of total mitochondrial protein contents.
However, in our case, excess of copper may promote the activity of cytochrome c oxidase that naturally requires copper as a cofactor and functions as its terminal electron acceptor (Pilon et al.
Deoxyribonucleic acid was extracted using modified organic extraction method, amplified by polymerase chain reaction with cytochrome c oxidase III-specific primers.
Valproate-induced hepatic failure in a case of cytochrome c oxidase deficiency.