is a plant-based alkaloid that, like varenicline, is a partial agonist of nicotinic acetylcholine receptors.
As it has not been used extensively in Oceania, research was funded by the Health Research Council of New Zealand to investigate the use of cytisine
for smokers in New Zealand (NZ).
Among study participants who resumed smoking after completing treatment, the median time to relapse was significantly longer with cytisine
(53 days) than with nicotine replacement (11 days).
West R, Zatonski W, Cedzynska M, et al Placebo-controlled trial of cytisine
for smoking cessation.
A direct method and ICER tables for the cost-effectiveness of smoking cessation interventions in general populations: application to a new cytisine
trial and other examples.
The compelling rationale for bringing cytisine
to market is not that its efficacy is superior to that of current pharmacotherapies, but that the latter are unavailable to many smokers because of their cost.
In the study researchers found that a nicotine-like drug, cytisine
, specifically activated nicotinic receptors in the hypothalamus - a brain center that controls feeding in rodents.
Every part of the tree is poisonous including the sweet-tasting seeds, which contain an alkaloid called cytisine
, which is highly dangerous to children.
The compound cytisine
, an extract of acacia seeds that has been used in Eastern Europe for more than 40 years as an aid to smoking cessation, was found effective in the first placebo-controlled randomized trial of the agent that meets modern regulatory standards.
4 relative difference in smoking cessation between cytisine
and placebo was higher than previous studies have shown for varenicline (2.
The SDSU study examined what effect cytisine
had on alcohol consumption in mice and in rats in separate trials.
The reviewers found only one trial of another nicotine agonist, cytisine
, that met the reviews' inclusion criteria.