disulfide bridge

(redirected from cystine bridge)
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bridge

 [brij]
1. a fixed partial denture; see illustration.
A bridge unit serves to restore a functional unit by replacing one or more missing teeth. A fixed bridge consists of abutment and pontic teeth splinted together. From Darby and Walsh, 1995.
2. a protoplasmic structure uniting adjacent elements of a cell, similar in plants and animals.
conjugative bridge in bacterial conjugation, a connection formed between two bacterial cells by the attachment of an F pilus from an F+ cell to an F cell.
disulfide bridge disulfide bond.

di·sul·fide bridge

1. a disulfide linkage between two cysteinyl residues in a polypeptide or oligopeptide or in a protein;
2. any disulfide linkage between any thiol-containing moieties of a larger molecule.
Synonym(s): cystine bridge

bridge

(brij)
1. The upper part of the external nose formed by the junction of the nasal bones.
2. The curved part of a pair of eyeglasses that rests on the bridge of the nose.
3. A narrow band of tissue.
4. A cast dental restoration that replaces missing teeth. The restoration is usually made of gold alloy, with or without a porcelain exterior, and is attached to adjacent or abutment teeth for support.
4. The use of a short-acting drug when treatment with a longer-acting drug must be temporarily interrupted or during the initiation of the long-acting drug before it reaches full therapeutic effectiveness.

Patient care

Bridging is commonly used for perioperative anticoagulation. In patients who have atrial fibrillation or a history of blood clotting, warfarin, which has a relatively long half-life, is withheld several days before surgery. The bridge consists of the administration of low-molecular-weight heparins (LMWHs), which have a shorter half-life, until about 12 hr before the procedure in order to prevent clotting. At a safe time after the operation, LMWHs are reinstituted until warfarin reaches therapeutic levels, e.g., an international normalized ratio of 2 or more. The duration of bridging therapy varies but is typically between 2 days and 1 week.

Enlarge picture
BRIDGING
5. An exercise for activating the abdominal and hip extensor muscles. The patient lies on his back with knees flexed and feet flat against a horizontal surface, such as a floor, bed, or plinth (treatment table). The patient then lifts his hips while his feet, shoulders, and head maintain contact with the surface. Bridging is often recommended as part of preprosthetic training for patients with transtibial or transfemoral lower extremity amputations. See: illustration

CAUTION!

Bridging should always be performed while the prosthesis is removed.

disulfide bridge

Disulfide bond.

bridge

1. pons.
2. a protoplasmic structure uniting adjacent elements of a cell, similar in plants and animals.
3. dental prosthesis for the replacement of missing teeth.

disulfide bridge
disulfide bond.
β-γ bridging
one of the dysproteinemias in which there is no clear separation electrophoretically between the β2 and γ1 globulins. The cause is an increase in IgA or IgM, or both, and this is almost pathognomonic for chronic active hepatitis.