cysteamine


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cysteamine

 [sis-te´ah-mēn″]
a sulfhydryl amine that is part of coenzyme A; it reduces intracellular cystine levels and is used in treatment of nephropathic cystinosis; administered orally.

cys·te·a·mine

(sis-tā'a-mēn),
2-Aminoethanethiol; a sulfhydryl compound used experimentally to produce ulcers in rats and as a radioprotective agent; antidote to acetaminophen.

cysteamine

[siste′ämēn′]
a sulfhydryl amine that is part of coenzyme A. It reduces intracellular cystine levels and is used in treatment of nephropathic cystinosis. It is administered orally.

cysteamine

A stable aminothiol and metabolite of the amino acid cysteine.

Physiologic role
Cysteamine forms coenzyme A by combining with pantothenate and adenosine triphosphate.

Potential therapeutic role
Cysteamine has been in clinical trials for managing Batten disease, cystinosis, non-alcoholic steatohepatitis and Huntington's disease.

cysteamine

Mercaptamine, a drug used to treat NEPHROPATHIC CYSTINOSIS and prescribable only by urological specialists. A brand name is Cystagon.
References in periodicals archive ?
9] reported that adition of thiol components such as cysteamine to IVM medium improved embryo production.
The university team has modified the drug to target cysteamine directly into the cells, aiming to improve its absorption into the body, reduce the amount needed to be taken and lower the side effects.
The present study is a fundamental research which could be used in the measurement of cysteamine present in biological specimens at clinical laboratories and research centers", Chekin added.
Cysteamine was observed to be weakly genotoxic when cells were treated for 12 hr.
Cysteamine eye-drops dissolve corneal cystine crystals and prevent blindness.
The special cysteamine drops work by flushing toxic crystals out of the body that would otherwise build up, leading to blindness and organ failure.
Evaluation of cysteamine associated with different energy patterns in diets for broiler chickens.
Sustained levels of cysteamine have not historically been achieved in the majority of patients in this population.
The normal fertilization rate of goat oocytes can be increased by supplementation of media by cysteamine (45, 46).
Influence of trehalose, taurine, cysteamine and hyaluronan on ram semen: Microscopic and oxidative stress parameters after freeze-thawing process.
Nasdaq:RPTP) has announced that it has enrolled the first patient in a pivotal Phase 3 clinical trial of its proprietary delayed-release oral formulation of cysteamine bitartrate ("DR Cysteamine") in patients with nephropathic cystinosis ("cystinosis").
The starting plasma solution and the washing solutions all contained 1 mmol/L phenylmethylsulfonyl fluoride, 10 mmol/L [epsilon]-aminocaproic acid, 10 mmol/L EDTA, and 5 mmol/L cysteamine hydrochloride.