cyclosporine


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cyclosporine

 [si″klo-spōr´in]
a cyclic peptide from an extract of soil fungi, an inhibitor of t cell function; used as an immunosuppressant to prevent and treat rejection in organ transplant recipients and to treat severe psoriasis and as a disease-modifying antirheumatic drug.

cy·clo·spor·ine

(sī'klō-spōr'ēn),
A cyclic oligopeptide immunosuppressant produced by the fungus Tolypocladium inflatum Gams; used to inhibit organ transplant rejection.

cyclosporine

/cy·clo·spor·ine/ (-spor´ēn) a cyclic peptide from an extract of soil fungi that selectively inhibits T cell function; used as an immunosuppressant to prevent rejection in organ transplant recipients and to treat severe psoriasis and severe rheumatoid arhtritis.

cyclosporine

(sī′klə-spôr′ēn, -ĭn) also

cyclosporin

(-ĭn)
n.
An immunosuppressive drug obtained from certain soil fungi, used mainly to prevent the rejection of transplanted organs.

cyclosporine

Immunology A cyclic undecapeptide, which induces potent T-cell immunosuppression; cyclosporine mitigates GVHD, allograft rejection, ulcerative colitis, autoimmune disease, schistosomiasis; it may be of use in aplastic anemia, in combination with antilymphocyte globulin and methylprednisone for psoriasis Adverse effects Nephrotoxicity, HTN, neurotoxicity–eg, tremor, seizures, encephalopathy, headache, coma, hyperlipidemia, hyperkalemia, hypomagnesemia, HTN, anemia, anaphylaxis, nausea, paresthesias, ↑ EBV, lymphoma, pseudolymphoma, fluid retention, thromboses, hirsutism, liver toxicity Lab ↑ Creatinine, ↑ uric acid, ↑ BR, ↑ cholesterol. Cf Tacrolimus.

cy·clo·spor·ine

(sī'klō-spōr'ēn)
A cyclic oligopeptide immunosuppressant produced by the fungus Tolypocladium inflatum Gams; used to inhibit organ transplant rejection.

ciclosporin (cyclosporine) 

An immunosuppressant used in the treatment of the ocular manifestation of autoimmune diseases, uveitis, scleritis, keratoconjunctivitis sicca, ligneous conjunctivitis, and to prevent rejection of corneal grafts, etc. It is believed to exert its immunosuppressive effect by inhibiting the activation of cytotoxic T-lymphocytes. See immunosuppressants.

cy·clo·spor·ine

(sī'klō-spōr'ēn)
A cyclic oligopeptide immunosuppressant used to inhibit organ transplant rejection.

cyclosporine (sī´klōspor´ēn),

n brand name: Sandimmune;
drug class: immunosuppressant;
action: produces immunosuppression by inhibiting lymphocytes;
uses: to prevent rejection of tissues and/or organ transplants.

cyclosporine

a neutral cyclic peptide, the major metabolic product of the fungus Tolypocladium inflatum; a specific suppressor of the T lymphocyte response, important in tissue transplantation.
References in periodicals archive ?
Conclusion: Iatrogenic acute kidney damage is a major cause of morbidity in experimental animals exposed to such nephrotoxic drugs like amphotericin B and cyclosporine, used either alone or in combination.
Healing rates within 6 months were approximately 47% for the cyclosporine and prednisolone groups.
Ketoconazole, a synthetic imidazole agent with fungistatic action, inhibits cytocrome P450, increasing bio-availability of cyclosporine, thus reducing the dose of cyclosporine by approximately 70-85% from 10 mg/kg BID (Mathews and Sukhiani, 1997; Mathews et al.
In case series, patients taking stable doses of cyclosporine and prophylactic doses of colchicine exhibited toxicity when they took therapeutic doses of colchicine for gout exacerbations.
Conclusions: The occurrence of new onset hyperlipidaemia is similar in renal transplant recipients receiving either cyclosporine or tacrolimus in first 3 months post-transplant, but there is room for more research in this field as dyslipidaemia following successful renal transplantation is a frequent and persistent complication.
Cyclosporine (CsA) is one of the most widely used drugs in organ transplantation.
Phototherapy and topical treatments are options, but cyclosporine should not be used in breastteeding patients.
The topical cyclosporine group fared significantly better in the other study end points, which focused on eye dryness and tear production.
As noted above, cyclobenzaprine is a muscle relaxant, whereas cyclosporine is an immunosuppressive agent.
The BENEFIT trial compared three regimens - a more intensive and a less intensive course of belatacept treatment and a standard cyclosporine course.
In the July 15, 2008, issue of Cancer Research, researchers at Harvard Medical School found in animal and laboratory experiments that the anti-rejection, immunosuppressive drug cyclosporine ramps up expression of vascular endothelial growth factor (VEGF), which signals the growth of new blood vessels that can feed tumors.