cyclosporin


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cycloSPORIN1

[-spôr′ēn]
an alternative term for cyclosporin A, an immunosuppressive medication often administered after organ transplants.

cyclosporin2

[-spôr′in]
any of a group of biologically active metabolites of Tolypocladium inflatum Gams and certain other fungi. Nine have been identified and are designated cyclosporin A through I. The major forms are cyclosporin A and C, which are cyclic oligopeptides with immunosuppressive, antifungal, and antipyretic effects. As immunosuppressants, cycloSPORINE primarily affect T lymphocytes. They are widely used in organ transplantation to suppress rejection and are known to be a human carcinogen. Also spelled ciclosporin.

cyclosporin

Ciclosporin, an important immunosuppressant drug that has greatly reduced the rate of rejection of grafted organs such as kidneys and hearts. It acts by interfering with the multiplication of immunocompetent T lymphocytes. Brand names are Neoral and Sandimunn.
References in periodicals archive ?
Surgeons already use existing drugs such cyclosporin to achieve the same outcome after a transplant, to stop the body rejecting a donated organ.
Cyclosporin, methotrexate, oral corticosteroids, azathioprine,
Postextraction addition experiments (extracted water vs extracted whole blood or serum) to characterize ion suppression (n = 20) demonstrated < 10% mean ion suppression or enhancement for all analytes and internal standards except for cyclosporin D (46% suppression).
We decided to perform syngeneic PBSC transplantation using anti-thymocyte globulin (ATG) and cyclosporin A as an immunosuppressive regimen without high-dose chemotherapy conditioning.
Clinical and Economic Implications of Topical Cyclosporin A for the Treatment of Dry Eye.
Other immunosuppressive agents such as cyclophosphamide, cyclosporin, azathioprine and mycophenolate mofetil have been used to treat cases which are resistant to steroids.
A 10-year-old boy who was receiving cyclosporin after renal transplant presented with acute alteration in motor function, memory loss, and drowsiness.
The patent entitled "Novel Cyclosporin Analog Formulations" is the first patent to be issued in this patent family in the United States.
The subsequent chapters provide details on specific drugs: aminoglycosides, vancomycin, digoxin, lignocaine, procainamide, quinidine, phenytoin, carbamazepine, valproate, phenobarbitone, ethosuximide, cyclosporin, tacrolimus, lithium and theophylline.
The prescription eye medicine is basically topical cyclosporin.
2 mEq/L Specimen collection: Trough, before next dose Amitriptyline 120-250 ng/mL* 400 ng/mL* Imipramine 150-300 ng/mL 400 ng/mL Nortriptyline 50-150 ng/mL 200 ng/mL Protriptyline 75-250 ng/mL 400 ng/mL Doxepin 110-250 ng/mL* 400 ng/mL* *Parent drug plus demethylated metabolite OTHER DRUGS Cyclosporin 100-500 ng/mL Tacrolimus 5-20 mcg/L trough >25 mcg/L Theophylline 10-20 mcg/mL >25 mcg/mL Digoxin 0.
Of course, the latter two therapies can lead to skin cancer, and many of the drugs used to treat the disease, including methotrexate and cyclosporin, also have serious side effects, including increased risk of cancer.