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cycloserine |
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cycloserine /cy·clo·ser·ine/ (-se´ren) an antibiotic produced by Streptomyces orchidaceus or obtained synthetically; used as a tuberculostatic and in treatment of urinary tract infections. cycloserine (sī´klōserēn), n brand name: Seromycin Pulvules; drug class: antitubercular; action: inhibits cell wall synthesis, analog of D-alanine; uses: pulmonary tuberculosis. |
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9) act by inhibiting cell-wall synthesis and function (eg, penicillins, cephalosporins, bacitracin, vancomycin, cycloserine, polypeptides, antifungal polyenes), protein synthesis (eg, aminoglycosides, chloramphenicol, macrolides, tetracyclines, lincomycins), or nucleotide formation (eg, rifampin, isoniazid). Additional isolate susceptibility tests in Denver showed sensitivity to ethionamide, cycloserine, p-amino salicylic acid, clofazimine, levofloxacin, and pyrazinamide, but resistance to isoniazid, rifampin, streptomycin, amikacin/kanamycin, amoxicillin/clavulanate, and rifabutin. Cycloserine was used at a concentration of 30 [micro]g/mL (9). |
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