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cyclophosphamide |
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cyclophosphamide /cy·clo·phos·pha·mide/ (-fos´fah-mid) a cytotoxic alkylating agent of the nitrogen mustard group; used as an antineoplastic, as an immunosuppressant to prevent transplant rejection, and to treat some diseases characterized by abnormal immune function.
cyclophosphamide (sīklōfos´f n brand names: Cytoxan, Neosar, Procytox; drug class: antineoplastic alkylating agent; action: alkylates DNA, RNA; inhibits enzymes that allow synthesis of amino acids in proteins; uses: Hodgkin's disease; lymphomas; leukemia; cancer of female reproductive tract, lung, prostate; multiple myeloma; neuroblastoma; retinoblastoma; Ewing's sarcoma. cyclophosphamide a neoplastic suppressant used in the treatment of lymphomas and leukemias. |
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The treatment of choice is chemotherapy, which usually includes cyclophosphamide, vincristine, and prednisone. ovatus) were pooled and intraperitoneally injected into 15 ddY male mice (6-15 pooled ticks per mouse) treated with the immunosuppressant cyclophosphamide. Pharmacokinetic studies suggested a significant decrease in cyclophosphamide clearance, but no obvious affects on the other drugs. |
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