The research is expected to discover previously uncharacterized roles of cyclophilins
in Hepatocellular Carcinoma (HCC) to establish a new therapeutic strategy, and to explore potential synergistic combination treatments with minimal toxicity.
In present investigation the Cyclophilin
A (CypA) of white leg shrimp (Litopenaeus vannamei) has been cloned by rapid amplification of cDNA (RACE) and anchored PCR method.
Depletion of cyclophilins
B and C leads to dysregulation of endoplasmic reticulum redox homeostasis.
CPI-431-32 is a next-generation non-immunosuppressive cyclophilin
inhibitor shown to have best-in-class potency against hepatitis B virus and a significantly larger selective index compared to previously known cyclophilin
Characterization of the cyclophilin
gene family of Arabidopsis thaliana and phylogenetic analysis of known cyclophilin
Cyclosporine inhibits flavivirus replication through blocking the interaction between host cyclophilins
and viral NS5 protein.
Pfefferle S, Schopf J, Kogl M, Friedel CC, Muller MA, Carbajo-Lozoya J, Stellberger T, von Dall'Armi E, Herzog P, Rallies S, Niemeyer D, Ditt V, Kuri T, Zust R, Pumpor K, Hilgenfeld R, Schwarz F, Zimmer R, Steffen I, Weber F, Thiel V, Herrler G, Thiel HJ, Schwegmann-Wessels C, Pohlmann S, Haas J, Drosten C, von Brunn A (2011) The SARS-coronavirus-host interactome: Identification of cyclophilins
as target for pan- coronavirus inhibitors.
inhibitor DEBIO-025 and NIM811 another oral non-immunosuppressive cyclophilin
Inhibitor are being evaluated with encouraging preliminary results.
The researchers say that they analysed liver cells to determine which variant of cyclophilins
is critical for hepatitis C virus replication, and found that blocking cyclophilin
A leads complete inhibition of virus replication.
are a family of enzymatic proteins that assist in the folding and transport of other proteins synthesized within a cell.