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cyclopamine |
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cyclopamine a steroidal alkaloid in the plant Veratrum californicum responsible for the development of the cyclopian deformity caused by feeding the plant to pregnant ewes on the 14th day of pregnancy. |
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Phytoalkaloids like cyclopamine are present in a range of plants and result in severe birth defects of offspring when pregnant animals are exposed to them. In recent years, scientists have tested cyclopamine to see whether its assault on the fast-growing cells of embryos and fetuses might be turned against tumor cells, which also multiply rapidly. The report states that administration of a Hedgehog pathway inhibitor, cyclopamine, blocks the growth of the breast cancer cells that were isolated from those tumor tissues. |
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cyclopamine
