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cyclopamine

   Also found in: Wikipedia 0.01 sec.
cyclopamine
a steroidal alkaloid in the plant Veratrum californicum responsible for the development of the cyclopian deformity caused by feeding the plant to pregnant ewes on the 14th day of pregnancy.


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While monitoring recovering mice we noted that tumours began to recur in all cases except for those treated with Cyclopamine for a short period of time after tumour disappearance.
Phytoalkaloids like cyclopamine are present in a range of plants and result in severe birth defects of offspring when pregnant animals are exposed to them.
Cell lines were prepared from the yolk sac and exposed to Cyclopamine for one, two, and three days.
 
 
 
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