cyclopamine


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cyclopamine

a steroidal alkaloid in the plant Veratrum californicum responsible for the development of the cyclopian deformity caused by feeding the plant to pregnant ewes on the 14th day of pregnancy.
References in periodicals archive ?
Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport.
71) Cyclopamine, an inhibitor of Hedgehog, reduced tumor mass of xenografted invasive pancreatic cancers in nude mice.
Phytoalkaloids like cyclopamine are present in a range of plants and result in severe birth defects of offspring when pregnant animals are exposed to them.
Topical cyclopamine, topical tazarotene, and topical antioxidants all hold promise, said Dr.
Cyclopamine decreased cell number by half and decreased the percentage of late erythrocytes on each harvest day.
Cell lines were prepared from the yolk sac and exposed to Cyclopamine for one, two, and three days.
In recent years, scientists have tested cyclopamine to see whether its assault on the fast-growing cells of embryos and fetuses might be turned against tumor cells, which also multiply rapidly.
The hedge hog pathway drives the proliferation of cancer stem cells and has been a target for drug development for sometime, based on earlier work with the plant-derived substance, cyclopamine, a specific blocking agent of the hedge hog pathway.
This research opens the possibility of new anti-cancer therapies, specifically the use of RNA interference and of Cyclopamine, a plant product known to block Hedgehog pathway activity.
Moreover, inhibition of Hedgehog signaling with the small molecular cyclopamine caused a profound decrease in metastatic spread in this orthotopic xenograft model.
Using small-scale microarray technology, a panel of 96 cell cycle control genes was screened for changes in expression in the presence of cyclopamine.
The report states that administration of a Hedgehog pathway inhibitor, cyclopamine, blocks the growth of the breast cancer cells that were isolated from those tumor tissues.