are known for their role in synthesis of prostaglandins which have gastro protective activity.
Table 2: Expression of renal cyclooxygenases
(COX-1 and -2) in rats with PUUO at 9 and 15 weeks (mean ± SEM) [Table omitted]
Comparative pathophysiology and toxicology of cyclooxygenases
Since, the aging-related increased formation of ROS is reduced in the presence of inhibitors of either cyclooxygenases
or eNOS, it implies the involvement of cyclooxygenases
and uncoupled eNOS.
Nitric oxide synthases (NOS) and cyclooxygenases
(COX) are considered to have a significant role in the inflammatory milieu occurring in acute stroke.
They also discuss in vivo disease models used to study the role of cyclooxygenases
in gastrointestinal injury, inflammation, and pain.
25] Prostaglandins are synthesized from arachidonic acid by the action of cyclooxygenases
Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: effects on cytosolic phospholipase A(2), cyclooxygenases
The inhibition of various enzymes of the arachidonic acid cascade, among these the lipoxygenases and the cyclooxygenases
, might be a possible target.
Signaling pathways regulating aromatase and cyclooxygenases
in normal and malignant breast cells.
Nutritional and botanical modulation of the inflammatory cascade--eicosanoids, cyclooxygenases
, and lipoxygenases--as an adjunct in cancer therapy.
Lipsky LP, Abramson SB, Crofford L, Dubois RN, Simon LS, Van de Putte LB (1998) The classification of cyclooxygenases