cyclooxygenases (sīˈ·klō·
kˈ·s
·je·nāˑ·ss),
kˈ·s·je·nāˑ·ss),n.pl enzymes that are rate-limiting in the production of thromboxanes and prostaglandins from arachidonic acid. The constitutive form of these proteins is essential for maintaining homeostasis while the indu-cible form is expressed in leukocytes in response to an inflammatory stimulus, resulting in production of prostanoids. The activity of cyclooxygenases is inhibited by antiinflammatory drugs, such as aspirin, and corticosteroids interfere with gene expression of the inducible form of the enzyme.
)
Cyclooxygenase.
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