cyclooxygenase


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cyclooxygenase

 [si″klo-ok´sĭ-jĕ-nās]
an activity of the enzyme prostaglandin endoperoxide synthase.

pros·ta·glan·din en·do·per·ox·ide syn·thase

a protein complex that catalyzes two steps in prostaglandin biosynthesis; the cyclooxygenase activity (which is inhibited by aspirin and indomethacin) converts arachidonate and 2O2 to prostaglandin G2; the hydroperoxidase activity uses glutathione to convert prostaglandin G2 to prostaglandin H2.
Synonym(s): cyclooxygenase

cyclooxygenase

/cy·clo·oxy·gen·ase/ (-ok´sĭ-jen-ās) a component of prostaglandin synthase (q.v.).

cyclooxygenase

(sī′klō-ŏk′sĭ-jə-nās′, -nāz′)
n.
1. See COX-1.
2. See COX-2.

cyclooxygenase

[si′klō·ok′səjĕnās]
an activity of the enzyme prostaglandin endoperoxide synthase.

Cyclooxygenase

An enzyme, found in most tissues, that helps turn some fatty acids into protaglandins.
Mentioned in: Cox-2 Inhibitors
References in periodicals archive ?
46 g) showed the highest cyclooxygenase inhibitory activity and was further fractionated by MPLC on silica gel using hexane-acetone (10:1, 110 ml; 6:1, 350 ml; 3:1, 600 ml; 1:1, 400 ml) followed by 100% acetone (140 ml) and MeOH (100 ml).
Inhibition of 5-lipoxygenase and cyclooxygenase enzymes isolated from ram seminal vesicles by alkamides present in E.
Cyclooxygenase inhibitory and antioxidant bioassay-directed extraction and purification of celery seeds yielded sedanolide (1), senkyunolide-N (2), senkyunolide-J (3), 3-hydroxymethyl-6-methoxy-2,3-dihydro-1H-indol-2-ol (4), L-tryptophan (6), and 7-[3-(3,4-dihydroxy-4-hydroxymethyl-tetrahydro-furan-2-yloxy)-4,5-dih ydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy]-5-hydroxy-2-(4-hydro xy-3-methoxy-phenyl)-chromen-4-one (7).
Inhibition of heat-shock protein 70 induction in intestinal cells overexpressing cyclooxygenase 2.
2B), a selective inhibitor of cyclooxygenase at a concentration that completely inhibited the production of cylcooxygenase-derived factors (Cole et al.
Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells.
Giuliano F, Warner TD (1998) Ex-vivo assay to determine the cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs.
While many of her classmates were waiting tables at restaurants during the summer of 2004, Alicia Smith was in an NIEHS lab investigating how exposure to sodium arsenite regulates the procarcinogenic and proinflammatory enzyme cyclooxygenase 2.
Neither a muscarinic receptor antagonist nor a cyclooxygenase inhibitor altered the Ch1LW-induced relaxation.
A paper to be presented at the World Congress of Inflammation Societies in Vienna in October will report on BF-389's potent effect on the newly discovered cyclooxygenase II enzyme.
Overexpression of cyclooxygenase (COX)-2 has been implicated in many pathologic conditions, including cancer.
Cyclooxygenase (COX) is involvecl in the synthesis of prostaglandins.