cyclodextrin


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cyclodextrin

(sī-klō-dĕks′trĭn)
A molecule made of linked dextrose subunits that can be used in drug delivery in the body. Cyclodextrins have lipid centers surrounded by water-soluble exteriors. This combination allows fat-soluble medicines to be carried through the bloodstream to lipid-rich organs like the brain.
References in periodicals archive ?
Further current projects are exploring the capabilities of cyclodextrin in water or air treatment applications, for instance to filter unwanted odors or pollutants.
Badyal, Controlled Fragrant Molecule Release from Surface-Tethered Cyclodextrin Host-Guest Inclusion Complexes, ACS Appl.
Furthermore, the three hydroxyl groups on C6, C2 and C3 have different reactivities and this influences the chemistry that can be performed with cyclodextrin (Lindhorst, 2007) molecules.
Rational design of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 to increase alpha-cyclodextrin production.
Cyclodextrins are known as effective complexing agents, which have an ability to form inclusion complexes with various organic guest molecules that fit the size of the cyclodextrin cavity.
Lower loads resulted in better retention, irrespective of the type of cyclodextrin.
Wibaux and Paesen developed odor- and water-absorbing foams based on cyclodextrin coupled to polyurethane foams.
Cyclodextrins are interesting because they have a lipophilic central cavity and a hydrophilic exterior surface.
Franz Schardinger identified cyclodextrins in 1903 as products produced by the degradation of starch through the action of amylase enzyme cyclodextrin glycosyl transferase (CGTase) produced by the microorganism Bacillus macerans which may break a segment of the starch helix and join the end portions of the fragment in one cyclic molecule.
A review has described studies of the binding of cyclodextrin to protein, and almost all studies have identified amino acid residues as the main structural element interacting with cyclodextrin.
The composition is free of any cyclodextrin compounds and film-forming polymers.
CD can form inclusion complexes with lipophylic drugs that have physical, chemical, and biological properties dramatically different from those of either the parent drug/ligand or cyclodextrin.