cyclins


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Related to cyclins: cell cycle, M-cyclin, CDK, Cyclin dependent kinase

cyclins

(sī′klĭnz)
A group of intracellular proteins that regulate the cell cycle, i.e., cell growth and division. Some cyclins, including cyclins D and E, are overexpressed in human breast cancer cells.

cyclins

Regulatory subunits of the kinases involved in the eukaryotic cell cycle. Cyclins are proteins whose concentration in the cells increases and decreases in phase with the cell cycle. Passage through the cycle is controlled by cyclin-dependent kynase complexes which are inactive unless associated with a cyclin.

cyclins

a set of related proteins that regulate the passage of cells through the cell cycle by forming complexes with cyclin-dependent protein kinases.

cyclins-dependent protein kinase (Cdk)
forms complexes with cyclins to become active in activating stages of the eukaryotic cell cycle.
References in periodicals archive ?
The journal article is entitled "G(1) arrest of U937 cells by ONCONASE is associated with suppression of cyclin D3 expression, induction of p16(INK4A), p21(WAF1/CIP1) and p27(KIP) and decreased pRb phosphorylation".
The kinase activity of Cdk1 is controlled during the cell-cycle both by its association with cyclin B1 and by phohphorylation and dephosphorylation on residues Thr14 and Tyr15 crucial for the [G.
This is encouraging as Cyclacel makes progress in building a competitive pipeline in the cell cycle area with additional drug candidates from our CYC400 CDK inhibitor, CYC103 Cyclin Groove Inhibitor and CYC102 PCNA Inhibitor programmes.
In this research it was clearly shown that hyperplastic intima was mainly composed of VSMC, and cyclin [D.
3 mg/ml of dried plant material) which correlated with cyclin D1- and Cdc25A suppression and p21 induction.
This study demonstrates differences in cyclin D1 overexpression in both endometrial surface metaplasia and endometrial glandular hyperplasia and carcinoma.
NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/Gl-to-S-phase transition.
Their activities are tightly controlled by associated cyclins and other cell cycle regulators, including tumor suppressor genes such as p21 and the retinoblastoma gene product.
Osaka, Japan) has patented a novel protein having a high degree of homology to the amino acid sequence of the so-called cyclin box which is characteristic of cyclins: they are herein referred to as "human cyclin I" or "human cyclin I protein.
The discovery of CDKs and cyclins and their role in checkpoint control of the cancer cell cycle has been honored with the 2001 Nobel Prize for Medicine and Physiology.