CDKN2B

(redirected from cyclin-dependent kinase inhibitor 2B)

CDKN2B

A gene on chromosome 9p21 that encodes a member of the INK4 family of cyclin-dependent kinase inhibitors, which form a complex with CDK4 or CDK6, preventing activation of CDK kinases and thus acting as cell growth regulators by controlling cell cycle progression through G1. CDKN2B expression is dramatically induced by TGF beta, suggesting a role in TGF-beta-induced growth inhibition.
References in periodicals archive ?
2] Genes: Cdkn2a, cyclin-dependent kinase inhibitor 2A [Mus musculus gene]; Cdkn2b, cyclin-dependent kinase inhibitor 2B [Mus musculus gene]; CDKN2A, cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) [human gene]; CDKN2BB, cyclin-dependent kinase inhibitor 2B (melanoma, p16, inhibits CDK4) [human gene].
Full browser ?