CDKN2C

(redirected from cyclin-dependent inhibitor)

CDKN2C

A gene on chromosome 1p32 that encodes a member of the INK4 family of cyclin-dependent kinase inhibitors, which form a complex with CDK6 and to a lesser extent with CDK4, preventing activation of CDK kinases and thus acting as cell growth regulators by controlling cell cycle progression through G1. CDKN2C inhibits cell growth and proliferation with dependence on endogenous retinoblastoma protein.