CCND2

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CCND2

A gene on chromosome 12p13 that encodes a member of the highly conserved cyclin family, which regulates CDK kinases. Cyclin D2 forms a complex with and is a regulatory subunit of CDK4 or CDK6, which are required for cell cycle G1/S transition; it is thought to play a central role in germ cell proliferation. Cyclin D2 interacts with tumour suppressor protein Rb and is involved in its phosphorylation.

Molecular pathology
CCND2 is overexpressed in ovarian and testicular tumours.
References in periodicals archive ?
Transcription factor 4(TCF4), zinc finger E-box binding homeobox 1 (ZEB1), and cyclin D2 (CCND2) were the genes found to be most influenced by these miRNAs.
For example, one risk variant is located near CCND2, the gene encoding cyclin D2, a member of the cyclin family of proteins that regulate the cell cycle.
7) The cyclin D1-negative cases are usually positive for cyclin D2 or cyclin D3, which are occasionally expressed in other B-cell lymphomas, limiting the diagnostic usefulness of these studies.
Western blotting was used for determining specific protein levels associated with cell cycle (chk2, p53, p21, pl6, cdk6, cyclin D2 and cyclin E) and apoptosis (Bax, Bcl-2, Bcl-xl/xs, cytochrome c, caspase-9, -3.
However, for genes with very weak LD, such as cyclin D2 (CCND2; Figure 5B), many more sites will be required for a genetic association study because few sites within this gene are correlated.
6A) showed that cyclin D2, cyclin A, cyciin B1, Cdk1 (Cdc2), and PCNA in MCF-7 cells were time-dependently down-regulated by taiwanin A, whereas the protein level of phospho-Cdk1 increased.
Cyclin D2 is present in and essential for rodent beta cell replication and function, but the team showed that molecule is barely detectable in human cells, and beta cell replication could be sustained for at least four weeks in a model in which mice were transplanted with human beta cells engineered to overproduce cdk6.