cyclin D1


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cyclin D1

A 36-kD protein which regulates cyclin-dependent protein kinase activity in G1 of the cell cycle. As a proto-oncogene, it activates cell-cycle progression, and is implicated in the pathogenesis of parathyroid and other neoplasms.

Molecular pathology
Cyclin-D1 overexpression is due to bcl-1 rearrangement, t(11;14)(q13;q32), and is activated by chromosome inversion, which places it under the influence of the regulatory region of the PTH gene.

Abnormal expression
Cyclin D1 is not expressed in normal or reactive lymphoid tissues. It is overexpressed in parathyroid adenoma, some breast cancers, squamous cell carcinoma of head and neck, and mantle zone lymphoma, but less commonly in other lymphomas.
References in periodicals archive ?
In estrogen receptor-positive breast cancer cell lines, cyclin D1 and CDK4 and 6 promote phosphorylation of the retinoblastoma protein, cell cycle progression, and cell proliferation.
In estrogen receptor-positive (ER+) breast cancer cell lines, cyclin D1 and CDK4 & 6 promote phosphorylation of the retinoblastoma protein (Rb), cell cycle progression, and cell proliferation.
B p65, cyclin D1, and Bcl-2 was significantly downregulated in wogonin-treated cells compared with DMSO-treated ones ( P < 0.
Induction of G1 cell cycle arrest and cyclin D1 down-regulation in response to pericarp extract of Baneh in human breast cancer T47D cells.
8, 9) Cyclin D1 is a member of the cyclin D protein family.
Importantly, ERK5 is reported to target some well-known regulators related to cell proliferation, including nuclear factor (NF)-[kappa]B (NF-[kappa]B), c-Myc and cyclin D1 (17).
SUMMARY--The aim of the study was to determine the influence of RET, p27 and cyclin D1 on regional lymph node metastases in papillary microcarcinoma.
The aim of the present study was to search the association of intracellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), Cyclin D1, cathepsin D immunohistochemically with clinicopathological parameters in the patients diagnosed with invasive ductal breast carcinoma.
sup][7] Further study unveiled that CDCA7L could stimulate the extracellular signal-regulated kinase 1/2 signaling pathway and upregulate cyclin D1 expression.
To identify whether A2 can affect target genes of [beta]-catenin such as Cyclin D1 and c-Myc, the expression level of Cyclin D1 and c-Myc was examined.
Limited Tenders are invited for Supply of Daptomycin 350 mg Inj, p 53 monoclonal mouuse anti human conc, silver nitrate, TdT monoclonal anit human conc, cuvette (pkt of 150x40 nos), Cyclin D1 concentrated.