cyclin D1


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cyclin D1

A 36-kD protein which regulates cyclin-dependent protein kinase activity in G1 of the cell cycle. As a proto-oncogene, it activates cell-cycle progression, and is implicated in the pathogenesis of parathyroid and other neoplasms.

Molecular pathology
Cyclin-D1 overexpression is due to bcl-1 rearrangement, t(11;14)(q13;q32), and is activated by chromosome inversion, which places it under the influence of the regulatory region of the PTH gene.

Abnormal expression
Cyclin D1 is not expressed in normal or reactive lymphoid tissues. It is overexpressed in parathyroid adenoma, some breast cancers, squamous cell carcinoma of head and neck, and mantle zone lymphoma, but less commonly in other lymphomas.
References in periodicals archive ?
Chrysin plays an important role in the prevention of the growth of cancer cells, and it reduces the cyclin D1 gene.
Since rosamultic acid induced cell cycle arrest in sub-G1 (G0/G1) phase, therefore we also evaluated the effect of this triterpenes on the expression levels of the cell cycle related proteins including CDK4, CDK6 and cyclin D1 in SGC-7901 gastric cancer cells.
The same WGA products were used for a real-timebased assay to validate the amplification of the cyclin D1 (CCND1) [8] locus, and used to screen for mutations on exons 1, 9, and 20 of the phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) gene (see online Supplemental Table 5) and exons 5, 7, and 8 of the tumor protein p53 (TP53) gene by sequencing.
Levels of many STAT3-regulated gene products, including Bcl-2, cyclin D1, and survivin, were also reduced in SFN-treated cells.
Washington, Nov 30 ( ANI ): A new study has found that cyclin D1, a protein that helps push a replicating cell through the cell cycle also mediates the processing and generation of mature microRNA (miRNA).
The experiments targeted two related proteins, cyclin D1 (http://www.
Illinois) and cyclin D1 (clone SP4, Thermo Fisher Scientific, Fremont, California) by using established labeled polymer immunohistochemical staining technique.
The results from this study demonstrated that curcumin down regulates the transcription and translation of Notch-1 and its downstream genes, Hes-1, Hey-1, Hey-2 and cyclin D1, which results in osteosarcoma cell growth inhibition.
Increase in levels of cyclin D1 was noticed in response to IGF-1.
The treated cells were subjected to direct and indirect immunofluorescent assays for cyclin D1.
Nuclear galectin-3 expression is associated with cell proliferation, and this effect is mediated through enhanced cyclin D1 promoter activity (24).