Among 25 cases with cyclin D1 expression, 6 had metastases, whereas only 2 of 45 cases with no cyclin D expression had metastases ([chi square]-test: p=0.
Metastases were present in 6 of 25 cases with cyclin Dl expression and in only 2 of 45 cases with no cyclin D expression.
Amplification and expression of the human cyclin D
gene in esophageal cancer.
These data suggest that downregulation of cyclin D protein level by MRB is involved in the proteasomal degradation.
Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4.
Ongoing studies are assessing the role of cyclin D
, a CDK activator corresponding to progression through the cell cycle.
com)-- One of the researchers said, “Blocking cyclin D
represents a highly selective anticancer strategy that specifically targets cancer cells without significantly affecting normal tissues.
Material and Methods: Cyclin D, E, A, and B, and cyclin-dependent kinase inhibitor (CDK1) p16 and p21 levels were measured via flow cytometry in patients with chronic myeloid leukemia (CML) (n = 16) and multiple myeloma (MM) (n = 13), and in controls (n = 15).
Among all the cyclins expressed during the S phase, cyclin D expression was the lowest in the CML patients.
Daidzein treatment resulted in decreases in cyclin D, CDK2, and CDK4, whereas the expression of CDK6 and cyclin E was unchanged.
Antibodies against CDK1, CDK2, CDK4, cyclin A, cyclin B, cyclin D, cyclin E, p[21.
Cyclins and cancer, II: cyclin D
and CDK inhibitors come of age.