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A class of proteins involved in regulation of the cell cycle.


Any of a class of proteins that fluctuate in concentration at specific points during the cell cycle and that regulate the cycle by binding to a kinase.


one of a class of intracellular proteins that appear during the eukaryotic cell cycle. The cyclin concentration increases during the cycle until halfway to the mitosis stage, when it drops to zero. Cyclin may act as a molecular switch that activates mitosis when its concentration reaches a certain point.


A gene on chromosome 20pter-p12 that encodes a homotrimeric nuclear protein that is a cofactor of DNA polymerase delta. PCNA is ubiquinated in response to DNA damage and is involved in RAD6-dependent DNA repair.
References in periodicals archive ?
maritimum extracts down-regulated expression of cyclin B1 (proliferation regulating molecule) and Ki67 (nuclear antigen expressed by cancerous proliferating cells).
Cyclin D1 (Bcl1, PRAD1) protein expression in low-grade B-cell lymphomas and reactive hyperplasia.
Western blotting results showed that the expression of cyclin D1 in cells with miR-143 mimic were remarkably decreased compared with cells with mimic control (P < 0.
For all three primary monoclonal antibodies, the same manufacturer (Novocastra, Newcasde Upon Tyne, United Kingdom) was selected: monoclonal antibody for RET oncoprotein clone 3F8 P (HIER); p27 protein monoclonal antibody clone 1B4 P (HIER) W; and cyclin D1 monoclonal antibody clone P2D11F11 P (HIER/Enzyme) W.
For positive controls, tonsil tissue for ICAM-1, placenta for VCAM-1, an intestinal tissue diagnosed with mantle zone lymphoma for cyclin D1, a hepatic tissue for cathepsin D, breast tissue for ER/PR and positive stained breast carcinoma for cerbB2 were used.
The A and B interface is also well conserved and act as secondary binding site for other proteins while cyclin fold structural motif is also the part of both A and B domains.
To investigate whether CA blocked the progression through the cell cycle by inhibiting the levels of the Cyclins and consequently the activities of CDKs, we first performed immunoblot analysis of CA treated and control PT2 cells with specific antibodies directed against Cyclin A and B1.
The objectives of the presenting study were to investigate the expression of cyclin D1 in both BPH and PAC and correlate the results of cyclin D1 with the Gleason's score as well as clinical staging of PAC.
Cyclin D1 and E2 were not among the direct Bachl-targeted cell-cycle-related proteins identified in HEK293 cells [3].
The work supports the idea that cancer-causing proteins like cyclin D1 may drive cancer progression in part via miRNA biogenesis," he said.
Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations.
The expression levels of cyclin Dl and cyclin-dependent kinase 2 were increased.