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cyclin

   Also found in: Dictionary/thesaurus, Acronyms, Encyclopedia, Wikipedia 0.01 sec.
cyclin
[sī′klin]
one of a class of intracellular proteins that appear during the eukaryotic cell cycle. The cyclin concentration increases during the cycle until halfway to the mitosis stage, when it drops to zero. Cyclin may act as a molecular switch that activates mitosis when its concentration reaches a certain point.


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PPT upregulated while DPN downregulated cyclin D1 and proliferating cell nuclear antigen (PCNA).
Stimulation was further enhanced by increasing production of another cell cycle molecule called cyclin D1.
Paraffin-embedded specimens from inactive endometrium (n = 16), endometrial hyperplasia (n = 23) and endometrioid endometrial carcinoma (n = 39) were stained immunohistochemically for cyclin A, cyclin B1, cyclin D1, cyclin E, cdk2, p16, p21, p27, p53 and Ki67(MIB-1).
 
 
 
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