cyclic peptide


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cy·clic pep·tide

a peptide that forms a ring structure; for example, tyrocidin A, an antibiotic, is a cyclic decapeptide; valinomycin is a cyclic depsipeptide.
References in periodicals archive ?
APL-2 is a synthetic cyclic peptide conjugated to a polyethylene glycol polymer that binds specifically to C3 and C3b, effectively blocking all three pathways of complement activation (classical, lectin, and alternative).
The group identified a cyclic peptide that could bind to hair under shampooing conditions, which meant a low pH and in the presence of surfactants.
In a two-step process high target affinity and bioavailability are installed:1) Peptide macrocyclization for the stabilization of the irregular bioactive secondary structure2) Evolution of the cyclic peptide into a bioavailable macrocyclic compoundUsing a well-characterized model system developed in my lab, initial design principles will be elucidated.
Among poor sleepers, a higher proportion of patients tested positive for rheumatoid factor and anti-citrullinated cyclic peptide (anti-CCP) autoantibodies.
Facile synthesis of orthogonally protected amino acid building blocks for combinatorial N-backbone cyclic peptide chemistry.
Some rrs mutations also confer resistance to the cyclic peptide antibiotic CAP .
In our study, the cyclic peptide, Pep42, CTVALPGGYVRVC, was selected for its ability to target and internalize within the Glucose Regulated Protein 78 (GRP78) harboring tumor cell lines.
Chemicals called cyclic peptide inhibitors can stop sweet-toothed cancer cells from growing.
mMass as a software tool for the annotation of cyclic peptide tandem mass spectra.
In addition, during the quarter, Janssen-Cilag GmbH completed the acquisition of CorImmun GmbH, a privately held drug development company in Germany, with lead compound, COR-1, a small cyclic peptide, currently in early clinical development for the treatment of heart failure.
Cyclosporin A (CsA) is a 1202 Da cyclic peptide, widely used for preventing organ rejection following transplants.
Isolation, structural characterization, and properties of mattacin (polymyxin M), a cyclic peptide antibiotic produced by Paenibacillus kobensisM.

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