PDE3B

(redirected from cyclic nucleotide phosphodiesterase)
Also found in: Encyclopedia.

PDE3B

A gene on chromosome 11q15.1 that encodes a cyclic nucleotide phosphodiesterase, which plays a critical role in signal transduction, regulating intracellular cyclic nucleotide concentrations by hydrolysing second messengers cAMP and/or cGMP to AMP and GMP, and in turn regulating physiological processes. PDE3B may have a role in fat metabolism.
Mentioned in ?
References in periodicals archive ?
Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes.
The enzymes responsible for degrading cAMP are the cyclic nucleotide phosphodiesterases (PDEs), of which at least 11 different isoforms have been identified in humans.