cyclic neutropenia

cyclic neutropenia

n.

See periodic neutropenia.

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cyclic neutropenia

[sik′lik no̅o̅′trōpē′nē·ə]

a chronic type of neutropenia that abates and recurs, accompanied by malaise, fever, stomatitis, and various types of infections.

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neutropenia [noo″tro-pe´ne-ah]

diminished numbers of neutrophils in the blood.

congenital neutropenia infantile genetic agranulocytosis.

cyclic neutropenia a chronic form marked by regular, periodic episodic recurrences, associated with malaise, fever, stomatitis, and various infections. Called also periodic neutropenia.

drug-induced neutropenia that caused by medications; the most common mechanisms are immunological (formation of antibodies destructive to neutrophils or of immune complexes that bind to neutrophils), followed by inhibition of granulopoiesis and direct damage to bone marrow or precursor cells of the granulocytic series.

idiopathic neutropenia agranulocytosis.

Kostmann's neutropenia infantile genetic agranulocytosis.

malignant neutropenia agranulocytosis.

neonatal neutropenia, alloimmune neutropenia in the newborn due to in utero incompatibility between its immunoglobulin G antigens and those of the mother's blood; the mother's blood produces antibodies that cross the placenta and sensitize fetal neutrophils. Affected infants may have fever, pneumonia, septicemia, and other infections that can be fatal. The condition eventually resolves as the infant's immunoglobulin replaces that from the mother.

periodic neutropenia cyclic neutropenia.

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cyclic neutropenia (nōō´trpē´nē),

n a hereditary disease primarily afflicting young children and infants; characterized by flulike symptoms (weakness, tenderness in the pharynx, aching head, and fever) as well as stomatitis, periodontitis, and gingivitis; cycles every 3 to 4 weeks with painful lesions and damage to the alveolar bone; should be medicated with antibiotics prior to any oral surgery.

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cyclic

pertaining to or occurring in a cycle or cycles. The term is applied to chemical compounds that contain a ring of atoms in the nucleus.

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cyclic adenosine monophosphate (AMP)

see cyclic adenosine monophosphate.

cyclic guanosine monophosphate (cGMP)

see cyclic guanosine monophosphate.

canine cyclic hematopoiesis

an abnormality of hematopoietic stem cells that results in detectable, cyclic fluctuations in numbers of circulating neutrophils. Affected dogs have an increased susceptibility to infections. The condition is inherited as an autosomal recessive in collies where it is occurs with a distinctive silver-gray coat color; called also gray collie syndrome.

cyclic neutropenia

see canine cyclic hematopoiesis (above).

cyclic non-breeder cows

cows demonstrating estrus regularly but not being submitted for mating; deferral of mating.

cyclic nucleotide

see cyclic nucleotide.

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neutropenia

a diminished number of neutrophils in the blood.

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cyclic neutropenia

periodic neutropenia. See also canine cyclic hematopoiesis.

malignant neutropenia

agranulocytosis.

periodic neutropenia

see canine cyclic hematopoiesis.

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cyclic neutropenia

A disorder characterized by episodic severe neutropenia occurring in 3-4 wk cycles, accompanied by maturational arrest of myeloid precursors in BM Clinical Fever, oral ulceration, cervical lymphadenopathy, multiple acute local infections which are rarely fatal Management If symptomatic, antibiotics–eg, aminoglycosides, penicillin