cyclic guanosine monophosphate

guanosine /gua·no·sine/ (gwah´no-sēn) a purine nucleoside, guanine linked to ribose; it is a component of RNA and its nucleotides are important in metabolism. Symbol G.

---

cyclic guanosine monophosphate  3′,5′-GMP, cGMP, cyclic GMP; a cyclic nucleotide that acts as a second messenger similar in action to cyclic adenosine monophosphate but generally producing opposite effects on cell function.

guanosine monophosphate  (GMP) a nucleotide important in metabolism and RNA synthesis.

guanosine triphosphate  (GTP) an energy-rich compound involved in several metabolic reactions and an activated precursor in the synthesis of RNA.

---

cyclic guanosine monophosphate

n.

Cyclic GMP.

---

cyclic guanosine monophosphate (cGMP),

a substance that mediates the action of certain hormones in a manner similar to that of cyclic adenosine monophosphate. In response to the stimulation of cholinergic receptors in a parasympathetic nerve, guanylate cyclase triggers the conversion of guanosine triphosphate to cGMP with the release of various enzymes. Atropine, an anticholinergic drug, can block cholinergic stimulation by means of this process.

---

guanosine [gwah´no-sēn]

a nucleoside, guanine riboside, one of the major constituents of RNA.

cyclic guanosine monophosphate a cyclic nucleotide, guanosine 3′,5′-cyclic monophosphate, an intracellular “second messenger” similar in action to cyclic adenosine monophosphate; the two cyclic nucleotides activate different protein kinases and usually produce opposite effects on cell function. Abbreviated 3′,5′-GMP, cGMP, and cyclic GMP.

guanosine monophosphate (GMP) a nucleotide important in metabolism and RNA synthesis.

guanosine triphosphate (GTP) a nucleotide required for RNA synthesis and involved in energy metabolism.