Vericiguat (BAY 1021189) is an investigational, oral stimulator of the soluble guanylate cyclase
Karpen, "Cyclic NucleotideGated Channels Colocalize with Adenylyl Cyclase
in Regions of Restricted Camp Diffusion," J.
Thus, Glutaminyl Cyclase
(QC) inhibitors are attractive drug candidates.
To verify further the involvement of nitric oxide/cyclic guanosine monophosphate signaling pathway, the i-NAME (an inhibitor of NO synthase) 100 [micro]M or MB (a soluble guanylyl cyclase
PQ912 is a small molecule that targets glutaminyl cyclase
(QC), an enzyme that catalyzes the formation of pyroglutamated Abeta, thus preventing the formation of highly toxic Abeta species including soluble oligomers.
Soluble adenylyl cyclase
defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases.
5) The cause is believed to involve a point mutation on chromosome 20 (20q12-q13) within the Gs alpha region; as a result of the mutation, the activity of the Gs protein, and thus of adenyl cyclase
, is increased.
i/o] proteins, which are directed to inhibition of adenylate cyclase
[11, 12], while the [A.
Ishikawa, Isoform-targeted regulation of cardiac adenylyl cyclase
, J Cardiovasc Pharmacol.
The company says that GCC-B1 can find one cancer cell in 10,000,000 normal cells by detecting the presence of guanylyl cyclase
C (GC-C), which is found on metastatic colorectal cancer cells.
1A] is both an autoreceptor on the neuronal cell body and a postsynaptic membrane receptor that reduces adenylyl cyclase
cyclizes N-terminal glutamine to pyroglutamic acid in such peptides as TRH.