CUL5

(redirected from cullin-5)

CUL5

A gene on chromosome 11q22.3 that encodes cullin-5, a core protein of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate ubiquitination and subsequent proteasomal degradation of targeted proteins. Cullin-5 may contribute to catalysis by positioning the substrate and the ubiquitin-conjugating enzyme. ECS (SOCS1) may direct ubiquitination of JAK2 and be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55-kDa protein.
References in periodicals archive ?
The Western blotting showed that the expression of Cullin-5, a cell proliferation indicator, was higher in the [MPC.
Furthermore, the Cullin-5 and Bip were down-regulated by the TM treatment in the [MPC.
Cullin-5 is a core component of Elongin-Cullin 2/5-SOCS-box protein E3 ubiquitin-protein ligase complexes, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins [29].