CUL3

(redirected from cullin-3)

CUL3

A gene on chromosome 2q36.2 that encodes cullin-3, a core protein of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin-3 may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The ubiquitin-protein ligase activity of the complex depends on neddylation of the cullin subunit, and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1.
References in periodicals archive ?
OBJECTIVE: We investigated the cross-regulations among NRF2, NRF1, and KEAP1, a cullin-3 adapter protein that allows NRF2 to be ubiquinated and degraded by the proteasome complex, in arsenic-induced antioxidant responses.
Kelch-like ECH-associated protein 1 (KEAP1), a cytoplasmic protein, serves as a substrate-adaptor molecule for cullin-3 based ubiquitin E3 ligase (Kobayashi et al.