CUL2

(redirected from cullin-2)

CUL2

A gene on chromosome 10p11.21 that encodes cullin-2, a core protein of multiple cullin-RING-based ECS (elonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin-2 may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The ubiquitin-protein ligase activity of the complex depends on neddylation of the cullin subunit, and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1.
References in periodicals archive ?
This function is suggested by the ability of SOCS box to bind to Elongin B and C, two proteins that associate with the E3 ubiquitin ligase, cullin-2 (Ram and Waxman, 1999; Shuai, 1999).