CUL7

(redirected from cullin 7)

CUL7

A gene on chromosome 6p21.1 that encodes cullin-7, a core protein of an E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin-7 interacts with TP53, CUL9 and FBXW8 proteins.

Molecular pathology
CUL7 mutations cause 3M syndrome type 1.