cryptococcal meningitis


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cryptococcal meningitis

Neurology An opportunistic infection of the meninges and spinal cord by Cryptococcus neoformans At-risk Pts AIDS, lymphoma, DM Clinical Severe headache, confusion, photosensitivity, blurred vision, fever, speech difficulties Management Amphotericin B plus flucytosine, then consolidation with fluconazole or itraconazole Prognosis Untreated, coma, death

cryptococcal meningitis

Fungal meningitis due to Cryptococcus neoformans. A rare cause of disease in healthy hosts, cryptococcal meningitis is an opportunistic infection usually seen in patients with advanced AIDS or patients taking high-dose steroids. It usually presents with gradually progressive headache and fever. The serum cryptococcal antigen test is a useful screening test. The diagnosis is established by the results of analysis and culture of cerebral spinal fluid.

Treatment

Treatment options include amphotericin B, often with flucytosine. Fluconazole and/or related antifungals are sometimes used for maintenance therapy.

See also: meningitis
References in periodicals archive ?
A case of cryptococcal meningitis developed after shortterm therapy of steroid in a patient with autoimmune hemolytic anemia.
Outcomes of cryptococcal meningitis in Uganda before and after the availability of HAART.
The prognostic factors of cryptococcal meningitis in HIV-negative patients.
Justice was subsequently diagnosed with cryptococcal meningitis.
Cryptococcosis is the most life-threatening opportunistic infection in AIDS patients; about 6% to 10% of them will develop cryptococcal meningitis.
Table 1 Emergencies in HIV-infected people Emergencies related to HIV-therapy * Lactic acidosis * Abacavir hypersensitivity reaction * Indinavir-induced nephrolithiasis * Rash by NNRTI [right arrow] Maculopapular rash [right arrow] Stevens-Johnson Syndrome Emergencies related to opportunistic infections * Ocular emergencies [right arrow] Cytomegalovirus retinitis [right arrow] Varicella zoster * Pulmonary emergencies [right arrow] Pneumocystis carinii pneumonia [right arrow] Bacterial pneumonia * Central nervous system emergencies [right arrow] Cerebral toxoplasmosis [right arrow] Cryptococcal meningitis Emergencies related to immune reconstitution syndrome
The donation was limited to cryptococcal meningitis (excluding thrush), only South Africans would benefit and the donation would last for two years until Pfizer's patent expired.
In this study, CNS toxoplasmosis caused 28% of seizures; cryptococcal meningitis, 13%.
Approved January 29, 1990 for the treatment of oropharyngeal and esophageal candidiasis and for the treatment of cryptococcal meningitis.
Opportunistic infections are common as the defence system is broken by HIV (AIDS) virus, pneumocystis carini pneumonia (PCP) and fungal or cryptococcal meningitis or meningoencephalitis and kaposi sarcoma are serious complications.
VT-1129 is a potent and safe, oral, preclinical development candidate for the treatment of cryptococcal meningitis.
headache, vomiting, neck pain/ stiffness, seizures, focal neurological signs and confusion)[3]--unlike bacterial meningitis, which usually presents more acutely, but similar to cryptococcal meningitis (CM).