cryoglobulins


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Related to cryoglobulins: cryoglobulinemia

cry·o·glob·u·lins

(krī'ō-glob'yū-linz),
1. Abnormal plasma proteins (paraproteins), now grouped with gamma globulins, characterized by precipitating, gelling, or crystallizing when serum or solutions of them are cooled; distinguished from Bence Jones proteins by their larger molecular weight (approximately 200,000 compared with 35,000-50,000); they may appear in patients with multiple myeloma.
2. Any globulin that forms a gel or flocculent precipitate on cooling.

cry·o·glob·u·lins

(krī'ō-glob'yū-linz)
Abnormal plasma proteins characterized by precipitating, gelling, or crystallizing when serum or solutions containing them are cooled; may appear in patients with multiple myeloma.

cryoglobulins

GLOBULINS that precipitate from solution and become visible on cooling
References in periodicals archive ?
Although the link between mixed cryoglobulinemia and PN is well-known, the lack of cryoglobulin measurements is one limitation of our study
The most common of these are preanalytic and analytic cryoglobulin precipitates.
In viral infections (HCV, CMV, HIV), development of TTP seems to be linked to immune phenomena such as the presence of cryoglobulins and anticardiolipin antibodies as well as endothelial damage [7].
Also order a viral screen and a cryoglobulins assay, Dr.
Plasma samples were thawed, and each sample was centrifuged to remove cryoglobulins.
Sedimentation rate, antinuclear antibodies (ANA), rheumatoid factor (RF), cryoglobulins, anticentromere antibody, Scl-70, antiphospholipid and anticardiolipin antibodies were all normal or negative.
Symptomatic MC has been observed in up to 21 percent of patients with HCV, and the percentage of HCV patients with detectable cryoglobulins may be as high as 54 percent [29].
Q The beginning of our procedure for testing a blood sample for cryoglobulins calls for heating the drawtube at 37[degrees]C for at least one hour.
In this syndrome, cryoglobulins composed of HCV immune complexes, immunoglobulins, rheumatoid factor, and complement are deposited in tissues.
Cryoglobulins in chronic hepatitis C patients are cryoprecipitable immune complexes that contain IgM rheumatoid factor (IgM anti-IgG), HCV-RNA and core proteins associated with the IgG antibodies that are produced during the immune response of B-cells against HCV antigens.
Initial laboratory studies should include a complete blood count, metabolic panel, liver function tests, fasting blood glucose, inflammatory markers such as erythrocyte sedimentation rate and C-reactive protein, cold agglutinins, and cryoglobulins.