cryoglobulinemia


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cryoglobulinemia

 [kri″o-glob″u-lin-e´me-ah]
the presence of cryoglobulin in the blood, associated with a variety of clinical manifestations including Raynaud's phenomenon, vascular purpura, cold urticaria, necrosis of extremities, bleeding disorders, vasculitis, arthralgia, neurologic manifestations, hepatosplenomegaly, and glomerulonephritis.

cry·o·glob·u·lin·e·mi·a

(krī'ō-glob'yū-li-nē'mē-ă),
The presence of abnormal quantities of cryoglobulin in the blood plasma.

cryoglobulinemia

/cryo·glob·u·lin·emia/ (-glob″u-lin-e´me-ah) the presence in the blood of cryoglobulin,which is precipitated in the microvasculature on exposure to cold.

cryoglobulinemia

[krī′ōglob′yoo͡linē′mē·ə]
Etymology: Gk, kryos + L, globulus, small sphere; Gk, haima, blood
the presence of cryoglobulins in the blood. Presence of cryoglobulins may be associated with a variety of clinical disorders including Waldenström's macroglobulinemia, hepatitis C, multiple myeloma, and leukemia.

cryoglobulinemia

Primary cryoglobulinemia Hematology A condition caused by proteins that precipitate in vivo on cooling of acral parts, which are often associated with immune complex-related disease; cryoglobulinemia has been divided into 3 clinical forms Clinical Pain, cyanosis, arthralgias, vascular purpuras, cold intolerance, HTN, CHF Lab ↓ C4 and other complement proteins
Cryoglobulinemia
Type I Monoclonal cryoglobulinemia Underlying disease is often malignant; IgG (malignant myeloma), IgM macroglobulinemia or lymphoma/CLL, rarely others (eg IgA nephropathy), benign monoclonal gammopathy
Type II Poly-monoclonal cryoglobulinemia A complex of immunoglobulins, eg mixed IgM-IgG, G-G, A-G or other combinations that may be associated with lymphoreticular disease or connective tissue disease (rheumatoid arthritis, Sjögren syndrome, mixed essential cryoglobulinemia)
Type III Mixed polyclonal-polyclonal cryoglobulinemia Mixed IgG & IgM, ± IgA, due to rheumatoid arthritis, SLE, Sjögren syndrome, EBV, CMV, subacute bacterial infections, poststreptococcal, crescentic and membranoproliferative glomerulonephritides, DM, chronic hepatitis, biliary cirrhosis

cry·o·glob·u·lin·e·mi·a

(krī'ō-glob'yū-li-nē'mē-ă)
The presence of abnormal quantities of cryoglobulin in blood plasma.
Synonym(s): cryoglobulinaemia.

Cryoglobulinemia

Condition in which protein in the blood forms particles in the cold, blocking blood vessels and leading to pain and numbness of the extremities.

cryoglobulinemia

the presence of cryoglobulin in the blood, which is precipitated in the microvasculature upon exposure to cold.
References in periodicals archive ?
PegIFN[alpha]/ribavirin/protease inhibitor combination in severe hepatitis C virus-associated mixed cryoglobulinemia vasculitis.
The first patient in the high-dose cohort -- a plasma therapy-resistant aHUS patient with additional complicating disorders including hepatitis C, cryoglobulinemia and lymphoma -- has also completed treatment with OMS721.
When the cause of the CV cannot be identified, the disease is termed "idiopathic" or "essential" cryoglobulinemia (4).
The disorders include SLE, antiphospholipid syndrome (APS), Sjogren's syndrome, systemic sclerosis (SSc), Still's disease, AAV, Behcet's disease, cryoglobulinemia, poly/dermato-myositis, scleroderma, as well as pemphigus vulgaris, bullous pemphigoid, epidermolysis bullosa, ITP, and thrombotic thrombocytopenic purpura.
Doctors found that the patient suffered from cryoglobulinemia, a condition that make her body produce huge numbers of a particular antibody, according to the report published in the (http://www.
Many illnesses can cause cryoglobulinemia, including hepatitis C infection, rheumatoid arthritis, and multiple myeloma (4).
Plasmapheresis is used in the treatment of various diseases such as Goodpasture's syndrome, Hemolytic-uremic syndrome, Cryoglobulinemia, Hyperleukocytosis and many more.
Subjects were excluded if they had impaired healing caused by diabetes or peripheral vascular disease; were immunocompromised or were taking immunosuppressants; had neuropathy; were receiving renal dialysis; had cold intolerance; had blood dyscrasias, cryoglobulinemia, cryofibrino-genemia, or a collagen or autoimmune disease; were unable to give informed consent; or were in a trial evaluating other plantar wart treatments.
Cryoglobulinemia and cutaneous vasculitis in human brucellosis.
HCV is the most common cause of mixed essential cryoglobulinemia, which is characterized by production of immune complexes containing HCV particlews, anti-HCV, immunoglobulins, rheumatoid factor, and complement.